Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Another example of tangled proteins in neurodegenerative diseases

24.08.2004


Tangled strands of proteins called amyloid are found in the brain tissues of patients with a variety of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. One such protein is tau, now known to participate in tangle formation in Alzheimer’s patients. Another is alpha-synuclein, whose mutations cause Parkinson’s disease and dementia with Lewy bodies. In a paper published in the current issue of the Journal of Alzheimer’s Disease, researchers from the Tokyo Institute of Psychiatry, the Tokyo Metropolitan University, and RIKEN Harima Institute show that alpha-synuclein can also enhance microtubule formation, similar to tau.



Alpha-Synuclein was originally found in Alzheimer’s disease brains by Kenji Uéda et al. Microtubules are cytoskeletal polymers essential for axonal transport and neuronal function. Writing in the article, Kenji Uéda, Ph.D., states, "Now we can see a striking resemblance between alpha-synuclein and tau: both have the same physiological function and pathological features, making abnormal structures in diseased brains known as synucleinopathies and tauopathies. The discovery of a physiological role for alpha-synuclein may provide a new dimension in researches into the mechanisms of alpha-synuclein-associated neurodegenerative diseases."

"These novel and important findings offer a new window to explore the normal physiology of these diseases" stated George Perry, editor-in-chief, JAD.

George Perry, Ph.D. | EurekAlert!
Further information:
http://www.case.edu

More articles from Health and Medicine:

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

nachricht Study advances gene therapy for glaucoma
17.01.2018 | University of Wisconsin-Madison

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Novel chip-based gene expression tool analyzes RNA quickly and accurately

18.01.2018 | Medical Engineering

Scientists on the road to discovering impact of urban road dust

18.01.2018 | Ecology, The Environment and Conservation

Gran Chaco: Biodiversity at High Risk

17.01.2018 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>