Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New compound could give some types of cancer the one-two punch

23.08.2004


Ohio State University researchers are working on developing a multi-purpose cancer drug that might one day scale back the number of medications some cancer patients need to take.



In laboratory tests, a dual-action compound called OSU 111 has shown promise in killing prostate cancer cells. "It had a direct toxic effect on cancer cells, and also prevented angiogenesis – the formation of new blood vessels from pre-existing ones," said Tom Li, the study’s lead investigator and an associate professor of pharmacy at Ohio State. "It’s like using one stone to kill two birds."

Li presented the results on August 22 in Philadelphia at the summer meeting of the American Chemical Society.


OSU 111 is a variation on a theme – Li and his colleagues created OSU 111 using a known anti-cancer compound, SU-5416, as a model. Although SU-5416 showed promise in preclinical studies, it did not have the kind of far-reaching effectiveness that researchers had hoped for.

But SU-5416 does provide a good blueprint by which researchers can create dozens of analogs – compounds structurally similar, but with slightly different chemical compositions. "We’ve made close to 50 different analogs by modifying SU-5416," Li said.

Laboratory experiments show that OSU 111 is one of the most promising analogs for killing cancer cells Li’s team has found so far. When treated with OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said. "This compound stopped cell division in its tracks," he said.

OSU 111 induces apoptosis – cell suicide – in cancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cells from forming new blood vessels.

Scientists are looking for alternatives to established anti-cancer drugs, such as Taxol, which is used to kill cancer cells in ovarian, breast and lung tissue. Drugs like Taxol come from natural sources, and supplies are sometimes extremely limited. Also, synthetic versions of these drugs can be very difficult to make.

Providing a drug with more than one effect could also benefit cancer patients who are inundated with medications.

"Many clinical trials that test new cancer treatments use a combination of drugs – one to prevent the growth of new blood vessels, for example, and another to keep cancer cells from dividing and spreading," Li said. "One drug with dual activity means that the body only has to deal with a single compound, and that could eliminate a lot of complexity in terms of giving medication to patients, the body’s ability to absorb a drug and also side effects.

"We want to find a drug with a dual purpose," he continued. "Angiogenesis is very prominent in many cancers, particularly prostate cancer. Pure anti-angiogenic compounds haven’t been that successful; somehow cancer cells still find a way to form blood vessels."

Li and his colleagues are continuing to look for even more potent analogs based on the structure of SU-5416. "We’re developing small, easy-to-make compounds that are similar to established drugs, but hopefully much easier to come by," he said.

Li conducted this work with Ohio State colleagues Bulbul Pandit, Zhigen Hu, Zili Xiao and Christine Cheah; and Dan Sackett, of the Laboratory of Integrative and Medical Biophysics at the National Institute of Child Health and Human Development.

Tom Li | EurekAlert!
Further information:
http://www.osu.edu

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>