Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New compound could give some types of cancer the one-two punch

23.08.2004


Ohio State University researchers are working on developing a multi-purpose cancer drug that might one day scale back the number of medications some cancer patients need to take.



In laboratory tests, a dual-action compound called OSU 111 has shown promise in killing prostate cancer cells. "It had a direct toxic effect on cancer cells, and also prevented angiogenesis – the formation of new blood vessels from pre-existing ones," said Tom Li, the study’s lead investigator and an associate professor of pharmacy at Ohio State. "It’s like using one stone to kill two birds."

Li presented the results on August 22 in Philadelphia at the summer meeting of the American Chemical Society.


OSU 111 is a variation on a theme – Li and his colleagues created OSU 111 using a known anti-cancer compound, SU-5416, as a model. Although SU-5416 showed promise in preclinical studies, it did not have the kind of far-reaching effectiveness that researchers had hoped for.

But SU-5416 does provide a good blueprint by which researchers can create dozens of analogs – compounds structurally similar, but with slightly different chemical compositions. "We’ve made close to 50 different analogs by modifying SU-5416," Li said.

Laboratory experiments show that OSU 111 is one of the most promising analogs for killing cancer cells Li’s team has found so far. When treated with OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said. "This compound stopped cell division in its tracks," he said.

OSU 111 induces apoptosis – cell suicide – in cancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cells from forming new blood vessels.

Scientists are looking for alternatives to established anti-cancer drugs, such as Taxol, which is used to kill cancer cells in ovarian, breast and lung tissue. Drugs like Taxol come from natural sources, and supplies are sometimes extremely limited. Also, synthetic versions of these drugs can be very difficult to make.

Providing a drug with more than one effect could also benefit cancer patients who are inundated with medications.

"Many clinical trials that test new cancer treatments use a combination of drugs – one to prevent the growth of new blood vessels, for example, and another to keep cancer cells from dividing and spreading," Li said. "One drug with dual activity means that the body only has to deal with a single compound, and that could eliminate a lot of complexity in terms of giving medication to patients, the body’s ability to absorb a drug and also side effects.

"We want to find a drug with a dual purpose," he continued. "Angiogenesis is very prominent in many cancers, particularly prostate cancer. Pure anti-angiogenic compounds haven’t been that successful; somehow cancer cells still find a way to form blood vessels."

Li and his colleagues are continuing to look for even more potent analogs based on the structure of SU-5416. "We’re developing small, easy-to-make compounds that are similar to established drugs, but hopefully much easier to come by," he said.

Li conducted this work with Ohio State colleagues Bulbul Pandit, Zhigen Hu, Zili Xiao and Christine Cheah; and Dan Sackett, of the Laboratory of Integrative and Medical Biophysics at the National Institute of Child Health and Human Development.

Tom Li | EurekAlert!
Further information:
http://www.osu.edu

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>