Cross-section of an aneurysm superimposted over aorta and branching vessels from an atherosclerotic mouse. Lipids in aneurysm and atherosclerotic lesions appear in red. Credit: Lei Zhao, Tim Cyrus, Rolf Grabner/Nature Medicine 10(9): 966-73
Possible implications for some anti-inflammatory drugs used in fighting cardiovascular disease
Very little is known about how aortic aneurysms initially form and progress. Now, researchers from the University of Pennsylvania School of Medicine have shown in an atherosclerotic animal model that susceptibility for developing aneurysms increases significantly when an inflammation pathway important in asthma is activated. Mice without the inflammation gene were protected from aneurysms.
Colin D. Funk, PhD, former Professor of Pharmacology and Medicine, and Lei Zhao, MD, PhD, Research Associate, both in Penn’s Center for Experimental Therapeutics, report their findings in this week’s online publication and the September issue of Nature Medicine. Funk is now the Canada Research Chair in Molecular, Cellular and Physiological Medicine, Queen’s University, Kingston, Canada.
Karen Kreeger | EurekAlert!
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