In this retrospective study, eighty-eight patients with advanced hepatocellular carcinoma (HCC) were treated with long-term chemotherapy infusion into the hepatic artery, the main artery that supplies the liver. Known as hepatic arterial chemotherapy, this treatment requires a reservoir/pump system to supply the drug directly to the liver and the liver cancer. The reservoir port systems currently available have to be surgically implanted, making this treatment unavailable to many patients who were unable or unwilling to have the implant. Interventional radiologists -- vascular experts who are uniquely skilled in using the vascular system to deliver targeted treatments via catheter throughout the body -- adapted conventional venous ports to use in the arterial circulation. In this method, the interventional radiologist implanted the reservoir and then embolized – mechanically blocked – the arteries to the adjacent areas during the port placement to prevent the influx of drugs to areas outside of the liver. This is beneficial because the chemotherapy drug is only circulated to the organ with the cancer, so the drug does not harm healthy tissue throughout the body. This allows for a higher dose of chemotherapy drug to be used, because the drug is contained.
Hepatic Arterial Infusion Chemotherapy
The hepatic arterial infusion chemotherapy was initiated after reservoir implantation on an outpatient basis. The infusion protocols were decided for each patient by the physician in charge and chemotherapeutic agents were administered every 1–4 weeks. In 55 patients, cisplatin (10 mg/m2) and 5-fluorouracil (1,000 mg/m2) were given at 1 hour and 5 hours, respectively. In the other 33 patients, doxorubicin hydrochloride or epirubicin hydrochloride (10–20 mg/m2) were injected every 2–4 weeks in a "one-shot" manner.
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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28.03.2017 | Physics and Astronomy