The first study to compare survival between women with breast cancer whose treatment was based on consensus guidelines and those whose treatment was not shows that adhering to established guidelines improves survival and reduces the risk of recurrence. The study retrospectively examined whether the systemic therapy prescribed after surgery for women with early-stage breast cancer was consistent with treatment guidelines established for at the time. Systemic therapy includes chemotherapy and hormonal therapy and is designed to reach cancer cells that may have spread beyond the original tumor site. The study and an accompanying editorial will be published online August 2 in the Journal of Clinical Oncology (JCO) at http://www.jco.org.
Using medical records from Canada’s national health care system, Dr. Hébert-Croteau and her colleagues compared survival between 1,002 women with early breast cancer whose systemic treatment was delivered according to guidelines developed at the 1992 St-Gallen conference in Switzerland, and 380 women whose treatment differed from those guidelines. The study also included 159 women whose guideline adherence was unknown. The women were diagnosed between 1988 and 1994 with invasive breast cancer that had not spread to nearby lymph nodes.
Developed by consensus with input from oncologists in Europe and North America, the St-Gallen guidelines continue to be updated regularly and are considered among the best guidelines available. The guidelines stipulate whether a woman with node-negative breast cancer should, after surgery, receive tamoxifen, chemotherapy, neither (as is the case for women at low risk of recurrence), or both, depending on her risk.
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy