Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Recommendation Against Chemotherapy Sensitivity, Resistance Assays

04.08.2004


A new technology assessment from the American Society of Clinical Oncology (ASCO) states that the use of chemotherapy sensitivity and resistance assays (CSRAs) to select chemotherapeutic agents for cancer patients should not be undertaken outside of the clinical trial setting.

CSRAs are an in-vitro laboratory analysis used to help determine whether a specific chemotherapy regimen might inhibit tumor growth in a specific patient. This type of analysis contrasts with so-called empiric therapy, where chemotherapy treatment is chosen based on clinical literature describing outcomes achieved through a specific clinical trial.

ASCO underscores that the idea of tailoring treatment to individual patients – using effective agents while sparing unnecessary ones – has obvious and great appeal, but ultimately found that limitations in the literature about CSRAs, including small sample sizes, a lack of prospective studies, low yield of assays, and newer chemotherapy drugs that continue to be developed, cast doubt as to their actual effectiveness of CSRAs in determining a course of treatment.



Furthermore, for technically challenging assays that require colony formation, such as the human tumor cloning assay, and for surgical procedures including the sub-renal capsule assay, the success rate of the CSRA procedure is modest. In addition, preparation of the assay may involve complex laboratory work, limiting a broad application of the technology to routine clinical practice.

“I was glad to see that our technology assessment felt that clinical trial work on the use of chemotherapy and resistance assays should continue,” said Daniel Von Hoff, MD, FACP, Director of Arizona Health Science Center Cancer Therapeutics Program and Professor in the Department of Medicine, Molecular and Cellular Biology and Pathology, at The University of Arizona College of Medicine. “Obviously there is a great need for these assays particularly with the more targeted therapeutic agents that are being developed.”

ASCO recommends that oncologists instead make chemotherapy treatment recommendations based on published reports of clinical trials and a patient’s health status and treatment preferences.

ASCO does recommend that research into the potential for using CSRAs as a tool for determining appropriate treatment should continue. “As laboratory procedures become more advanced, better assays will be developed,” said Deborah Schrag, MD, a medical oncologist and member of the Health Outcomes Research Group at Memorial Sloan Kettering Cancer Center in New York City. “In addition, as more chemotherapy drugs become available, and treatment choices for oncologists become more complex, the rationale for developing CSRAs becomes more persuasive.”

ASCO defines a technology assessment as a process for determining whether a procedure is appropriate for broad-based use in clinical practices. Of an initial review of more than 1,100 articles, the ASCO Working Group found 12 articles that were relevant to include in a technology assessment of CSRAs and analyzed their results.

ASCO also released a new evidence-based technology assessment, Chemotherapy Sensitivity and Resistance Assays, the patient version of the clinical practice recommendations.

“American Society of Clinical Oncology Technology Assessment: Chemotherapy Sensitivity and Resistance Assays.” D. Schrag, MD, et al, Memorial Sloan-Kettering Cancer Center, New York, NY.

The guideline has been published ahead of print August 2, 2004, in the Journal of Clinical Oncology (JCO), the semi-monthly peer-reviewed journal of the American Society of Clinical Oncology (ASCO), the world’s leading professional society representing physicians who treat people with cancer.

| newswise
Further information:
http://www.asco.org
http://www.plwc.org
http://www.jco.org

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>