Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibiotics gain strength with natural compound

21.07.2004


More and more common antibiotics are losing their effectiveness because they are used too often, allowing bacteria to develop resistance to the drugs. A University of Rhode Island researcher has found a solution to this problem with a natural compound that boosts antibiotic strength from 100 to 1,000 times. While conducting research on infection prevention, URI Microbiology Professor Paul Cohen stumbled upon a compound -- lysophosphatidic acid -- that is naturally produced in the human body in great quantities wherever there is inflammation.



According to Cohen, bacteria are divided into two groups -- Gram-positive and Gram-negative -- based on the structure of their cell walls. When lysophosphatidic acid is administered in small amounts (80 micromolars), it sensitizes the Gram-negative bacteria 100 to 1,000 times so only small quantities of antibiotics are needed to kill the bacteria. When administered to fight Gram-positive bacteria, the compound kills the bacteria without needing any antibiotics.

"In combination with this compound, even older antibiotics become much more powerful," Cohen said. "It not only makes older antibiotics useful again, but it also allows them to be used in reduced dosages."


Lysophosphatidic acid is currently available commercially as a powder for researchers. Cohen holds a patent on its use with antibiotics. He said it can be formulated for a variety of applications, depending on where the infection is found.

"For cystic fibrosis patients, for instance, who often suffer from lung infections, it can be formulated for use as an inhalant. Burn patients or those with acne can use it as a lotion to rub on the skin. It can be applied in many ways," said the Narragansett resident who worked on the project with URI Professor David Laux, former URI technician Maryjane Utley and Danish researcher Karen Krogfelt of the Statenserum Institut in Copenhagen.

Cohen said that since the compound is naturally found in the bloodstream, it is non-toxic and patients should not be allergic to it. "We know it works in the test tube," he said, "but we still need to show that it works on animals. I’m sure that for surface diseases like acne, doctors would use it right away."

Cohen is seeking pharmaceutical-based partners to invest in the project and fund the next stage of research to bring this discovery to market.

Todd McLeish | EurekAlert!
Further information:
http://www.uri.edu

More articles from Health and Medicine:

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

nachricht Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>