Melanotan-1, a synthetic agent similar to the body’s hormone that regulates skin pigmentation, can be combined with UV-B light or sunlight, and appears to act synergistically in the tanning response to light, according to an article in the July issue of The Archives of Dermatology, one of the JAMA/Archives journals.
Melanotan-1 (MT-1) is a synthetic super-potent derivative of its natural counterpart, alpha-melanocyte-stimulating hormone, one of a family of hormones that induce pigmentation in the body. According to information in the article, the authors previously demonstrated that MT-1 can induce tanning in human volunteers who are known to tan easily in response to sunlight. All previously reported clinical trials with MT-1 were performed with volunteers who were instructed to avoid sunlight and use sunscreens with a sun-protective factor rating of 30 on all skin sites exposed to the sun. The effect of MT-1 when combined with either sunlight or simulated UV-B radiation had not been tested.
Robert T. Dorr, Ph.D., of the University of Arizona, Tucson, and colleagues performed three phase one clinical trials to demonstrate safety for MT-1 therapy combined with UV-B light or sunlight. In the first study, four subjects were randomized to 0.08 milligrams per kilogram of MT-1 per day administered by injection, and four others received injections of isotonic sodium chloride solution (solution containing the same concentration of salt as normal body fluids) for ten days. It was followed by neck irradiation with UV-B light.
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Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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