A previously unrecognized molecular structure on the surface of the human bacterial pathogen Group B Streptococcus (GBS) – the most common cause of sepsis and meningitis in newborn infants – is described by researchers at the University of California, San Diego (UCSD) School of Medicine in Proceedings of the National Academy of Sciences published online the week of July 19, 2004.
The new discovery has important implications for understanding the mechanism of infection and the design of vaccines to boost human immunity against this potentially devastating pathogen. For example, potential GBS vaccines currently in clinical trials have been developed without this new knowledge, which could possibly impact their effectiveness.
The findings are a collaborative effort between the laboratories of senior author Ajit Varki, M.D., UCSD professor of medicine and cellular and molecular medicine, and co-director of the UCSD Glycobiology Research and Training Center (GRTC), and Victor Nizet, M.D., associate professor of pediatrics, UCSD Division of Infectious Diseases and an attending physician at Children’s Hospital, San Diego. The two groups have been studying the phenomenon in which certain bacterial pathogens coat their surfaces with a thick capsule made of carbohydrate sugars similar to those found on the surface of human cells. In the case of GBS, the bacterial surface capsule contains sialic acid, a sugar that is also displayed prominently on the surface of all cells in the human body. It is believed that GBS uses sialic acid as a form of “molecular mimicry”, where the bacteria disguises itself to look more like human cells and thereby avoids recognition by the immune system.
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Earth Sciences
24.10.2016 | Life Sciences
24.10.2016 | Physics and Astronomy