Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene expression patterns may help predict risk and progression of prostate cancer

15.07.2004


According to a study published in the July 15 issue of the Journal of Clinical Oncology, genes expressed in benign tissue adjacent to prostate cancer tissue are much more similar to those expressed in prostate cancer tissue than previously thought. This finding, the first of its kind, may help predict populations both at risk for prostate cancer and for disease progression based on gene expression patterns, say researchers at the University of Pittsburgh.



"It is not clear what molecular events are responsible for the progression of prostate cancer to a lethal form of the disease," said Jian-Hua Luo, M.D., Ph.D., senior author of the study and assistant professor, department of pathology, University of Pittsburgh School of Medicine. "But by exploring the biology of prostate cancer through the identification of genes and patterns of gene expression, we can more precisely understand what genetic changes cause the disease to progress and develop therapeutic targets to prevent its progression at an earlier stage."

In the study, Dr. Luo, also director of the gene array laboratory at the University of Pittsburgh, and colleagues used high throughput quantitative analysis to genetically profile prostate cancer tissue and noncancerous prostate tissue samples. They analyzed 152 human tissue samples including 66 samples of prostate cancer tissue, 60 samples of benign prostate tissue adjacent to the tumor, 23 samples of donor prostate tissue free of genitourinary disease and three prostate cancer cell lines. Through the analysis, the researchers identified a set of 671 genes whose expression levels were significantly altered in prostate cancer tissue compared to disease-free tissue and found that patterns of gene expression in benign adjacent prostate tissue were much more similar to prostate cancer tissue than to disease-free tissue.


According to Dr. Luo, the gene expression patterns of benign adjacent tissue were significantly overlapped with those of prostate cancer and distinctly different than the disease-free tissue. Furthermore, the adjacent tissue was so genetically altered that it resembled a cancer field effect, undergoing genetic changes similar to prostate cancer, even though it was morphologically benign tissue.

"It appears that genetic alterations in the prostate occur in parts of the gland that otherwise look benign," said Joel Nelson, M.D., professor and chairman, department of urology, University of Pittsburgh and co-author of the study. "We have long suspected a so-called field change in the prostate gland containing cancer, meaning some alteration has occurred throughout the prostate tissue. This study lends support for such a hypothesis."

The researchers also created a gene model using GeneSpringTM software to predict the aggressiveness of the disease and found that the expression profile model was more than 80 percent accurate in predicting the aggressiveness of the disease.

"Since only a fraction of prostate cancers are metastatic, identifying variables that predict the behavior of a prostate cancer tumor based on gene expression patterns should prove important in clinical management of the disease," said Dr. Luo. "The results of this study are a first step in that direction."

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>