Link established between presence of a key protein and the aggressiveness of prostate cancer
Prostate cancer is much more likely to be aggressive if a key protein called Stat5 is found activated and in abundance in the cancer cells, report researchers from Georgetown Universitys Lombardi Comprehensive Cancer Center. By inhibiting this protein, called Stat5, doctors are exploring how to develop a new treatment strategy for advanced prostate cancer.
The new findings, reported in the July 15th issue of the journal Cancer Research, show that active Stat5 protein is particularly plentiful in high histological grade human prostate cancer. High histological grade prostate cancers have often already metastasized by the time of diagnosis and are typically more aggressive in growth.
"Currently, there are only few treatment options available for advanced prostate cancer," said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Lombardi Comprehensive Cancer Center. "If we can find a way to stop Stat5 from turning on in prostate cancer cells, we may be able to devise a new strategy for treating this disease."
Previous studies by Nevalainen show that when the "telephone line" that sends signals to turn Stat5 on is blocked, human prostate cancer cells die. When the line remains open for communication, allowing Stat5 to send cellular signals, prostate cancer cells stay alive and thrive. Nevalainens work is focused on finding ways to short-circuit the signals that turn on Stat5, thus killing prostate cells before they flourish.
In this study, human prostate cancer specimens, which are routinely collected during prostate cancer surgeries for analysis of the histological grade of each prostate cancer, were analyzed for activation of Stat5. Activation of Stat5 was then correlated statistically with the histological grade of each specimen.
Nevalainen sees dual possibilities for where the future of Stat 5 research may one day lead: development of potential treatments and identifying whether Stat5 could serve as an effective sign for diagnosing cancer. "We are in the process of determining whether activation of Stat5 in prostate cancer would serve as an effective prognostic biomarker. Development of additional diagnostics, beyond the PSA test, may help physicians on the frontlines of cancer detection."
Lindsey Spindle | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...