Prostate cancer is much more likely to be aggressive if a key protein called Stat5 is found activated and in abundance in the cancer cells, report researchers from Georgetown Universitys Lombardi Comprehensive Cancer Center. By inhibiting this protein, called Stat5, doctors are exploring how to develop a new treatment strategy for advanced prostate cancer.
The new findings, reported in the July 15th issue of the journal Cancer Research, show that active Stat5 protein is particularly plentiful in high histological grade human prostate cancer. High histological grade prostate cancers have often already metastasized by the time of diagnosis and are typically more aggressive in growth.
"Currently, there are only few treatment options available for advanced prostate cancer," said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Lombardi Comprehensive Cancer Center. "If we can find a way to stop Stat5 from turning on in prostate cancer cells, we may be able to devise a new strategy for treating this disease."
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