Catheter-directed embolization is a well-established interventional radiology technique used to treat arterial hemorrhage in a variety of areas in the body. Although embolization has been used for over 20 years to treat trauma victims with massive bleeding and to control hemorrhage after childbirth instead of emergency hysterectomy, the investigation of glue as an embolic agent is new. Embolization is particularly useful because in massive bleeding often there is so much blood coming at the surgeon that it is impossible for the surgeon to see the bleeding site from the outside in order to repair it. Since the interventional technique uses X-rays to visualize the inside of the vessel, the hemorrhage does not interfere with visualization and the interventional radiologist can pinpoint the location of the injury for embolization. In this minimally invasive treatment, a tiny nick is made in the skin and, using imaging, the interventional radiologist guides a catheter through the artery then releases clotting agents – coils or particles-- into the blood vessels. This slows the blood flow and stops the hemorrhage from the inside out. Most often coils or small particles are used as the embolic agent. These are effective in most cases, but there are times when these forms of embolization may not be technically possible. In this study, embolization with the glue, NBCA, successfully stopped arterial bleeding even when previous coil or particle embolization had failed. NBCA was useful in a large number of anatomic locations alone or in combination with other embolic agents, particularly microcoils.
N-butyl cyanoacrylate (NBCA) is a permanent liquid embolic material and tissue adhesive that is approved by the U.S. Food and Drug Administration for use in cerebral arteriovenous malformations. This article summarizes the initial experience with NBCA glue embolization in 16 patients with acute arterial hemorrhage. NBCA embolization was successful in 75 percent of the patients and failed in 12.5 percent in this study at the Los Angeles County and University of Southern California Medical Center.
About Transcatheter Embolization, Choice of Agent, and Possible Role for NBCA
23.03.2017 | Technische Universität München
How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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