UCSF scientists have identified a protein on T cells of the immune system that triggers type 1 diabetes in mice when it interacts with another protein in the pancreas. They have shown that blocking the interaction prevents development of diabetes without weakening normal immune defenses or causing measurable side effects. The success provides a promising strategy against human type 1 diabetes, since the T cell protein has a counterpart in the human immune system, the scientists say.
The research is being published online June 15 by the journal Immunity.
The T cell protein, known as NKG2D, is a receptor on the surface of CD8+ T lymphocytes. The second protein, called RAE-1, has been found on cells infected by bacteria or viruses where it binds to NKG2D, alerting CD8+ T cells and other immune system molecules to attack and eliminate the pathogen.
Wallace Ravven | EurekAlert!
A better way to measure the stiffness of cancer cells
01.03.2017 | Duke University
Humans have three times more brown body fat
01.03.2017 | Technische Universität München
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
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09.02.2017 | Event News
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