Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Scientists discover way to regulate the body’s energy expenditure


Scientists have discovered a protein that controls the amount of fat stored in the body, offering new clues for obesity treatments.

The research, published in this week’s Proceedings of the National Academy of Sciences, shows how the protein regulates the activity of a key gene responsible for maintaining the body’s temperature, called uncoupling protein 1 (UCP1).

The new protein, called RIP140, blocks the expression of UCP1, and causes the body to use up more energy and store less fat.

The team of scientists from Imperial College London, Kings College London, University of Cambridge, and Hammersmith Hospital, UK, conducted studies in transgenic mice born without RIP140, and in normal mice with RIP140. They found that mice without RIP140 were lean and showed resistance to high fat diet induced obesity.

On average, mice without RIP140 were 20 per cent lighter compared with normal mice and accumulated between 50 and 70 per cent less fat when compared with mice with RIP140, even though their food intake was similar.

Professor Malcolm Parker from Imperial College London, and based at Hammersmith Hospital, and one of the study’s authors comments: “This discovery could provide a novel approach to developing new obesity treatments. By reducing the levels of RIP140, it is possible to increase the activity of the UCP1 gene. UCP1 plays a key role in regulating energy balance in the body, and through this we can reduce body weight by increasing energy expenditure.

“Although these are very promising observations we do need to be careful in interpreting the results. The study was carried out in mice, which were born without RIP140, and it will be important to determine the consequences of blocking RIP140 action in adult animals.”

This work was supported by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council. Professor Parker and his team have recently signed a deal with CytRx, a US based biopharmaceutical company, to commercialise the results of this research.

Tony Stephenson | alfa
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>