Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genes Appear to Play a Role in Development of COPD

25.05.2004


A Wake Forest University Baptist Medical Center lung disease specialist reports that some smokers may be genetically predisposed to chronic obstructive pulmonary disease (COPD).



Jill Ohar, professor of pulmonology and critical care medicine at Wake Forest Baptist, presented her findings at the 100th International Conference of the American Thoracic Society in Orlando, Fla., today (May 25).

In her study, Ohar looked at more than 500 men and women age 40 and older who had smoked 20 years or more. She found that a variation of the macrophage scavenger receptor gene (MSR-1) is related to the development of airways obstruction in some patients who smoke cigarettes.


“We found a significant association between sequence variations in the MSR-1 gene and the presence of airways obstruction in smokers that may account for some of the variability in the development of COPD,” said Ohar. “This finding may help us to understand why some smokers develop COPD and improve our understanding of how the disease develops.”

Smoking is the leading cause of COPD, accounting for 90 percent of all cases. Yet, COPD affects only 15 percent to 20 percent of all smokers.

COPD is a group of lung diseases characterized by limited air flow with variable degrees of enlargement of the lung’s air sacs and lung destruction. When diseased, these air sacs, known as alveoli, are unable to completely deflate and are therefore unable to fill with fresh air to ensure adequate oxygen supply to the body. Emphysema and chronic bronchitis are the most common types of COPD.

Ohar was the lead investigator of a team including Arjun B. Chatterjee, M.D., Siquen L. Zheng, M.D., Deborah Meyers, Ph.D., Jing Feng Xu, M.D., and Eugene R. Bleecker, M.D., all from Wake Forest Baptist, and David Sterling, M.D., from the Saint Louis University School of Public Health.

The study was funded in part by the Selikoff Fund for Environmental and Occupational Cancer Research. Irving J. Selikoff. M.D. – the physician and scientist who led the worldwide struggle to prevent exposure to asbestos – created this fund to continue his program of applying the new discoveries in molecular biology for the detection, treatment and prevention of cancer and other diseases associated with the work and community environments.


About Wake Forest University Baptist Medical Center: Wake Forest Baptist is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University School of Medicine. It is licensed to operate 1,282 acute care, psychiatric, rehabilitation and long-term care beds and is consistently ranked as one of “America’s Best Hospitals” by U.S. News & World Report.

Jim Steele | newswise
Further information:
http://www.wfubmc.edu

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>