Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Researchers Find Combining Two Types of Radiation Therapy is Better for Treating Brain Cancer

21.05.2004


Adding stereotactic radiosurgery – which entails delivering radiation to specific points in the brain while sparing normal tissue – after whole brain radiation therapy helps certain patients with cancer that has spread to the brain live longer, says a new study by researchers at Thomas Jefferson University Hospital in Philadelphia.



In as many as one-third of all patients with lung and breast cancers, the disease spreads, or metastasizes, to the brain, leaving few good options. The disease causes neurological problems, and many patients live only about four months. Chemotherapy has been relatively ineffective in shrinking tumors and improving quality of life.

Between 1996 and 2001, the Radiation Therapy Oncology Group (RTOG), a federally funded clinical trials group, led by researchers at Jefferson Medical College and elsewhere randomly assigned 333 patients to receive either the standard whole brain radiation therapy alone, or whole brain radiation therapy followed by stereotactic radiosurgery.


The researchers found that patients with a single brain metastases who received radiosurgery immediately after whole brain radiation lived on average one to two months longer. Many of those had an improved quality of life after radiosurgery. Some of those with two or three brain metastases had some improvement in survival as well.

“It’s significant because it demonstrates for the first time a therapeutic benefit of stereotactic radiosurgery, which is a widely used technique,” says first author David Andrews, M.D., professor of neurosurgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia.

The researchers reported their results May 22, 2004 in the journal The Lancet.

“Our results establish a new standard of care for the treating oncologist and provide patients with realistic hope for an improved prognosis and better quality of life after treatment,” Dr. Andrews says.

“This is the first non-surgical treatment to show benefit for brain metastases in any group of patients,” says RTOG group chairman Walter J. Curran, Jr., M.D., professor and chair of radiation oncology at Jefferson Medical College and clinical director of Jefferson’s Kimmel Cancer Center.

Brain metastases affect as many as 100,000 individuals.

“It’s a real advance in the management of patients with brain metastases,” says Dr. Curran.

Other study authors include Adam Flanders, M.D., and Maria Werner-Wasik, M.D., Thomas Jefferson University; Charles Scott, Ph.D., American College of Radiology; Paul Sperduto, M.D., Metro Minneapolis CCOP; Laurie Gaspar, M.D., University of Colorado Health Sciences Center; Michael Schell, Ph.D., University of Rochester Cancer Center; William Demas, M.D., Akron City Hospital; Janice Ryu, M.D., University of California, Davis Medical Center; Jean-Paul Bahary, M.D., Notre Dame Hospital/University of Montreal; Louis Souhami, M.D., from McGill University; Marvin Rotman, M.D., SUNY Health Science Center, Brooklyn; and Minesh Mehta, M.D., University of Wisconsin Medical School.

Steven Benowitz | TJUH
Further information:
http://www.jeffersonhospital.org/news/e3front.dll?durki=17747

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>