Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Researchers Find Combining Two Types of Radiation Therapy is Better for Treating Brain Cancer

21.05.2004


Adding stereotactic radiosurgery – which entails delivering radiation to specific points in the brain while sparing normal tissue – after whole brain radiation therapy helps certain patients with cancer that has spread to the brain live longer, says a new study by researchers at Thomas Jefferson University Hospital in Philadelphia.



In as many as one-third of all patients with lung and breast cancers, the disease spreads, or metastasizes, to the brain, leaving few good options. The disease causes neurological problems, and many patients live only about four months. Chemotherapy has been relatively ineffective in shrinking tumors and improving quality of life.

Between 1996 and 2001, the Radiation Therapy Oncology Group (RTOG), a federally funded clinical trials group, led by researchers at Jefferson Medical College and elsewhere randomly assigned 333 patients to receive either the standard whole brain radiation therapy alone, or whole brain radiation therapy followed by stereotactic radiosurgery.


The researchers found that patients with a single brain metastases who received radiosurgery immediately after whole brain radiation lived on average one to two months longer. Many of those had an improved quality of life after radiosurgery. Some of those with two or three brain metastases had some improvement in survival as well.

“It’s significant because it demonstrates for the first time a therapeutic benefit of stereotactic radiosurgery, which is a widely used technique,” says first author David Andrews, M.D., professor of neurosurgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia.

The researchers reported their results May 22, 2004 in the journal The Lancet.

“Our results establish a new standard of care for the treating oncologist and provide patients with realistic hope for an improved prognosis and better quality of life after treatment,” Dr. Andrews says.

“This is the first non-surgical treatment to show benefit for brain metastases in any group of patients,” says RTOG group chairman Walter J. Curran, Jr., M.D., professor and chair of radiation oncology at Jefferson Medical College and clinical director of Jefferson’s Kimmel Cancer Center.

Brain metastases affect as many as 100,000 individuals.

“It’s a real advance in the management of patients with brain metastases,” says Dr. Curran.

Other study authors include Adam Flanders, M.D., and Maria Werner-Wasik, M.D., Thomas Jefferson University; Charles Scott, Ph.D., American College of Radiology; Paul Sperduto, M.D., Metro Minneapolis CCOP; Laurie Gaspar, M.D., University of Colorado Health Sciences Center; Michael Schell, Ph.D., University of Rochester Cancer Center; William Demas, M.D., Akron City Hospital; Janice Ryu, M.D., University of California, Davis Medical Center; Jean-Paul Bahary, M.D., Notre Dame Hospital/University of Montreal; Louis Souhami, M.D., from McGill University; Marvin Rotman, M.D., SUNY Health Science Center, Brooklyn; and Minesh Mehta, M.D., University of Wisconsin Medical School.

Steven Benowitz | TJUH
Further information:
http://www.jeffersonhospital.org/news/e3front.dll?durki=17747

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>