Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Urine protein test: A tipoff to kidney transplant rejection

19.05.2004


Johns Hopkins researchers have developed the basis of an inexpensive, simple urine test that identifies impending kidney failure or rejection following transplant surgery. Their work, presented this week in a special invited lecture to the American Transplant Congress in Boston, Mass., is based on proteins found in urine, and could lead to a urine test kit that may allow many patients to skip painful biopsies.



"This has the potential to radically change the way transplant patients are managed," says study co-author Ernesto P. Molmenti, M.D., Ph.D., associate professor of surgery at Johns Hopkins. "Frequent, noninvasive monitoring could allow doctors to better tailor immunosuppression drugs according to individual patient’s needs, prescribing lower doses to more stable patients or increasing doses for patients who show early signs of rejection."

Molmenti estimates that the test, when developed, will be far less expensive, safer and much less painful than a standard biopsy costing hundreds of dollars in which a doctor inserts a long needle into a patient’s side to obtain a kidney tissue sample.


To build a scientific foundation for the test, Molmenti and colleagues analyzed 34 urine samples from 32 kidney patients at various stages after transplantation. Seventeen patients had organ rejection and 15 had no rejection. Rejection status was confirmed by biopsy. The researchers identified thirteen possible protein markers that were present in most of the urine samples from patients who had organ rejection, but were absent from most non-rejection samples. Three other possible protein markers were found to be lower in patients’ urine with the onset of transplant rejection. A separate analysis using a combination of biomarker candidates in a panel correctly identified 91% of the 34 urine samples.

"Unlike kidney biopsy, a urine test is risk-free, presents no discomfort or restraints to the patients, and samples the entire kidney accurately," says study co-author William Clarke, Ph.D., assistant professor of pathology at Johns Hopkins.


Other researchers involved in the study were Benjamin C. Silverman; Zhen Zhang, Ph.D.; Daniel W. Chan, Ph.D.; and Andrew S. Klein, M.D.

Trent Stockton | EurekAlert!
Further information:
http://www.hopkinsmedicine.org/

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>