Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

ADAM: Good enzyme for Alzheimer disease

18.05.2004


A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model



Alzheimer Disease (AD), a progressive neurological disorder, is characterized by the presence of amyloid plaques in the brain. These plaques are comprised of aggregates of amyloid beta-peptides (AB peptides), which are believed to play a central role in disease development. Most strategies to prevent AD have been aimed at reducing the generation of amyloid beta-peptides. This is done by targeting specific enzymes, beta- and gamma-secretase, in the amyloid precursor protein (APP) degradation pathway, which sequentially cleave APP to form the Ab peptide. Falk Fahrenholz and colleagues at the University of Mainz, Germany, now provide evidence that targeting and alternative enzyme, alpha-secretase, might be a useful alternative strategy for reducing AB peptide. In the APP processing pathway, alpha-secretase cleavage of APP generates an alternative breakdown product of the protein that cannot generate AB peptide. Here the researchers use a mouse model deficient in or over expressing the gene ADAM10, which codes for alpha-secretase protein. In these studies, they find that moderate increased expression of ADAM10 in mice reduced AB peptide formation, prevented plaque formation, and, from a functional standpoint provided improvement in both long-term potentiation and cognitive impairment. On the other hand, mice lacking ADAM10 had increased number and size of amyloid plaques. The data here provide evidence that a-secretase might be a useful therapeutic target for AD, and also suggest that impairment of this enzyme might underlie some forms of the disease.

An accompanying commentary by Christian Haas and Stefan F. Lichtenthaler provides details on the APP degradation pathway and places this work and AD in this context.



TITLE: A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

AUTHOR CONTACT:
Falk Fahrenholz
University of Mainz, Mainz, Germany.
Phone: +49 6131-392-5833; Fax: +49 6131-392-5348; E-mail: bio.chemie@uni-mainz.de

View the PDF of this article at: https://www.the-jci.org/press/20864.pdf

ACCOMPANYING COMMENTARY: Amyloid at the cutting edge: activation of a-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

AUTHOR CONTACT:
Christian Haass
Ludwig-Maximilians-Universitat, Munich, Germany.
Phone: 49-89-5996-471; Fax: 49- 5996-415; E-mail: chaass@pbm.med.uni-muenchen.de

View the PDF of this commentary at: https://www.the-jci.org/press/21746.pdf

Laurie Goodman | EurekAlert!
Further information:
http://www.the-jci.org/press/20864.pdf
http://www.the-jci.org/press/21746.pdf

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>