High levels of troponin I (TNI) protein in the blood helps identify possible heart damage after cancer treatment, according to a report in todays rapid access issue of Circulation: Journal of the American Heart Association.
The report also suggests that tracking TNI levels can help doctors form a heart disease prevention plan for some chemotherapy patients. "Damage to the heart is one of the most worrisome long-term side effects of high-dose chemotherapy," said lead author Daniela Cardinale, M.D., deputy director of the cardiology unit at the European Institute of Oncology in Milan, Italy. "Therefore, it is important to identify biochemical markers that might indicate which patients are at greatest risk and how severe their heart disease might be."
TNI is a protein present exclusively in heart cells. The TNI blood concentration is a well-established marker of heart muscle injury thats widely used to diagnose and treat heart attacks and other acute coronary syndromes.
"The results of this study provide a rational need for doctors to use this marker to guide them in their cardiac evaluations and treatments of high-dose chemotherapy patients," Cardinale said.
Co-authors are: Maria T. Sandri, M.D.; Alessandro Colombo, M.D.; Nicola Colombo, M.D.; Marina Boeri, M.S.; Giuseppina Lamantia, M.D.; Maurizio Civelli, M.D.; Fedro Peccatori, M.D.; Giovanni Martinelli, M.D.; Cesare Fiorentini, M.D.; and Carlo M. Cipolla, M.D.
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