Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein marker predicts possible heart damage after chemotherapy

18.05.2004


High levels of troponin I (TNI) protein in the blood helps identify possible heart damage after cancer treatment, according to a report in today’s rapid access issue of Circulation: Journal of the American Heart Association.



The report also suggests that tracking TNI levels can help doctors form a heart disease prevention plan for some chemotherapy patients. "Damage to the heart is one of the most worrisome long-term side effects of high-dose chemotherapy," said lead author Daniela Cardinale, M.D., deputy director of the cardiology unit at the European Institute of Oncology in Milan, Italy. "Therefore, it is important to identify biochemical markers that might indicate which patients are at greatest risk and how severe their heart disease might be."

TNI is a protein present exclusively in heart cells. The TNI blood concentration is a well-established marker of heart muscle injury that’s widely used to diagnose and treat heart attacks and other acute coronary syndromes.


"Our study is the first to clearly show, in an adult population, that the risk of cardiac events in cancer patients can be predicted by evaluating the TNI release pattern after chemotherapy," Cardinale said.

In cancer patients who have had chemotherapy, physicians usually use extensive testing and expensive monitoring equipment to identify which patients may have cardiac toxicity, Cardinale said. These methods "have low sensitivity, poor predictive value and, in some cases, technical limitations. Moreover, these methods identify cardiac damage only when it has already occurred and, in most cases, is not reversible," she said. "Evaluating TNI value after chemotherapy is an easy, non-invasive, low-cost method that allows us to categorize the risk of cardiac events in cancer patients in the three years following chemotherapy."

Researchers took blood samples of 703 cancer patients to measure TNI soon after high-dose chemotherapy and one month later. TNI values higher than 0.08 nanograms per milliliter (ng/mL) were considered TNI "positive," while lower values were TNI "negative." They found that 145 patients (21 percent) were TNI positive right after chemotherapy, and 63 patients (9 percent) were positive immediately after chemotherapy and one month later.

The researchers found no significant reduction in heart function at the three-year follow-up in patients who were TNI negative. These patients had only a 1 percent incidence of cardiac events, such as heart attacks.

In contrast, the cardiac event incidence was 37 percent among the patients who were TNI positive immediately after chemotherapy and 84 percent among those who remained positive a month later.

Cardinale said the study has several important implications for cancer treatment:
  • TNI categorizes heart disease risk early, long before impairment in heart function and symptoms develop, and when many preventive treatments would probably help prevent long-term health effects.

  • TNI could assess and monitor the safety and effectiveness of different treatments.

  • Heart-protective therapies that might limit or prevent the TNI rise after chemotherapy, and heart treatments that interfere with TNI persistence could improve the future heart health of these patients.

"The results of this study provide a rational need for doctors to use this marker to guide them in their cardiac evaluations and treatments of high-dose chemotherapy patients," Cardinale said.

Co-authors are: Maria T. Sandri, M.D.; Alessandro Colombo, M.D.; Nicola Colombo, M.D.; Marina Boeri, M.S.; Giuseppina Lamantia, M.D.; Maurizio Civelli, M.D.; Fedro Peccatori, M.D.; Giovanni Martinelli, M.D.; Cesare Fiorentini, M.D.; and Carlo M. Cipolla, M.D.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

UCLA engineers use deep learning to reconstruct holograms and improve optical microscopy

22.11.2017 | Medical Engineering

Watching atoms move in hybrid perovskite crystals reveals clues to improving solar cells

22.11.2017 | Materials Sciences

New study points the way to therapy for rare cancer that targets the young

22.11.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>