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Genes to be ’flipped’ for drug-free treatment


The body’s own defences could be programmed to attack disease to order if two University of Leeds’ scientists succeed in proving their innovative theory.

Dr Graham Cook and Dr Erica de Wynter from the Molecular Medicine Unit, University of Leeds

Dr Graham Cook and Dr Erica de Wynter from the Molecular Medicine Unit have secured £125,000 to investigate the unique way antibody genes are assembled and how they can be harnessed to fight disease.

Scientists don’t often get funding for research where there is no preliminary data or background information but the pair have been funded by the Wellcome Trust’s Showcase scheme to research new ways to repair damaged immune systems.

Their research into ‘flipping genes therapy’ met the Trust’s criterion of being ‘speculative, novel, adventurous, innovative’.

Dr Cook said antibodies can be made to respond to every kind of pathogen. “Antibodies are created by taking bits of genes and reassembling them into different combinations, like a giant Lego set. If we can understand the mechanism by which genes are ‘flipped’ in this way, we can insert genes for the body to naturally rearrange, delivering treatments directly to the immune system.”

If their idea works, it could open the door to new therapies for treating immune-deficiency disorders and even provide a treatment for cancers of the immune system, by adding genes to make the cancerous cells die.

“The benefit of this kind of treatment is that it would use the cell’s natural mechanism to help fight disease,” said Dr de Wynter. “Our body uses this system to produce diversity, an insurance system against the ever changing pathogens it has to fight. Our problem is we want to specify the mechanism to create just one antibody, and while we believe it can work, we’ve now got to prove it. We think we can prove our idea is possible in the next two years.”

Vanessa Bridge | University of Leeds
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