Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genes to be ’flipped’ for drug-free treatment

10.05.2004


The body’s own defences could be programmed to attack disease to order if two University of Leeds’ scientists succeed in proving their innovative theory.


Dr Graham Cook and Dr Erica de Wynter from the Molecular Medicine Unit, University of Leeds



Dr Graham Cook and Dr Erica de Wynter from the Molecular Medicine Unit have secured £125,000 to investigate the unique way antibody genes are assembled and how they can be harnessed to fight disease.

Scientists don’t often get funding for research where there is no preliminary data or background information but the pair have been funded by the Wellcome Trust’s Showcase scheme to research new ways to repair damaged immune systems.


Their research into ‘flipping genes therapy’ met the Trust’s criterion of being ‘speculative, novel, adventurous, innovative’.

Dr Cook said antibodies can be made to respond to every kind of pathogen. “Antibodies are created by taking bits of genes and reassembling them into different combinations, like a giant Lego set. If we can understand the mechanism by which genes are ‘flipped’ in this way, we can insert genes for the body to naturally rearrange, delivering treatments directly to the immune system.”

If their idea works, it could open the door to new therapies for treating immune-deficiency disorders and even provide a treatment for cancers of the immune system, by adding genes to make the cancerous cells die.

“The benefit of this kind of treatment is that it would use the cell’s natural mechanism to help fight disease,” said Dr de Wynter. “Our body uses this system to produce diversity, an insurance system against the ever changing pathogens it has to fight. Our problem is we want to specify the mechanism to create just one antibody, and while we believe it can work, we’ve now got to prove it. We think we can prove our idea is possible in the next two years.”

Vanessa Bridge | University of Leeds
Further information:
http://reporter.leeds.ac.uk/498/s4.htm

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>