Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dampened hopes for transplanting bone marrow stem cells in heart attacks

06.05.2004


There is little, if any, evidence that adult stem cells can build other cells in an adult organism than those formed in the organs they themselves come from. At any rate, blood stem cells do not convert to heart muscle cells in a damaged heart, which was previously hoped. This has been shown by a research team from the Stem Cell Center at Lund University in Sweden in an article in Nature Medicine.



During the end of the 1990s and early 2000s scientists nourished great hopes that adult stem cells would be able to develop into all sorts of cells. If so, it would not be necessary to use the ethically more problematic embryonic stem cells. However, newer studies have shown that while adult stem cells are very good at producing different types of cells in their own respective organs, they have little or no ability to form cells in other organs.

“Both we and two American research teams have used various methods to replicate a study from three years ago that appeared in Nature. It was about transplanting blood stem cells to create new heart muscle cells to repair a heart after a heart attack. But all of our results univocally indicate that this is not possible,” says Jens Nygren. He is a doctoral student and part of research team headed by Professor Sten Eirik Jacobsen at the Stem Cell Center.


What the Lund scientists have found is that the transplanted cells that remain in the infarcted area retain their identity as blood cells. On the other hand, outside the infarcted area a so-called fusion did occur between the transplanted cells and heart muscle cells.

Such fused cells can sometimes look as if they had been formed from a transplanted stem cell. In other words, fusions may explain the first promising studies: the scientists believed they were looking at cells produced by maturation of blood stem cells, whereas in actual fact they were seeing a tiny number of fused cells.

Now it is time for second thoughts, and these might affect the many large-scale patient trials that were initiated during the hopeful period. In Sweden there is only one entirely new trial underway, and it can easily be discontinued, but in Germany and elsewhere a huge number of patients have already had blood stem cells transplanted into their heart, and more transplants are in planned. The question is whether there is any reason to continue these trials, or whether they should be ended. There are some indications that bone marrow transplants have a certain positive effect on the heart function after an infarction, but the mechanism behind this remains an open question.

Sten Eirik Jacobsen’s research team is now primarily focusing on how blood production from stem cells is regulated. They are also going to carry on their work to understand what fusion between bone marrow cells and heart musculature might entail, both in adult hearts and in fetal development.

Ingela Björck | alfa
Further information:
http://www.stemcell.lu.se

More articles from Health and Medicine:

nachricht Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Simple processing technique could cut cost of organic PV and wearable electronics

06.12.2016 | Materials Sciences

3-D printed kidney phantoms aid nuclear medicine dosing calibration

06.12.2016 | Medical Engineering

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>