Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Radiologists provide safe delivery method for gene therapy

03.05.2004


Computed tomography (CT)-guided injections offer a safe delivery method for gene therapy in patients with metastatic kidney cancer, according to a study in the May issue of the journal Radiology.



Gene therapy involves introducing genetic material directly into cells to fight disease. "The new gene therapies offer promise for controlling certain types of cancer, but delivering the agents directly into tumors poses its own set of challenges," said the study’s lead author, Robert D. Suh, M.D., who is an assistant clinical professor of radiology and director of thoracic interventional services at the David Geffen School of Medicine at University of California, Los Angeles (UCLA). "As research in gene therapy, or immunotherapy, progresses, we need a good gene therapy delivery mechanism."

Treatment of metastatic kidney cancer is difficult because the disease is largely resistant to chemotherapy. The only Food and Drug Administration (FDA)-approved immunotherapeutic treatment, recombinant interleukin-2 (IL-2), has a response rate of only 15 percent when administered intravenously, and its use is limited by significant and occasionally life-threatening side effects. Researchers have developed several gene therapy agents to improve the effectiveness and minimize the side effects of IL-2. UCLA’s technique involves injecting an IL-2-encoded recombinant gene directly into cancer cells.


The researchers assessed the feasibility of using CT guidance to safely position a needle in both superficial and deep tumor sites to deliver gene therapy (IL-2 plasmid DNA).

"The CT images enabled us to precisely target the tumor, eliminating any guesswork about where to angle the needle and how deeply to inject the therapy," said Dr. Suh.

Twenty-nine patients with kidney cancer that had spread to the chest or abdomen received up to three cycles of six weekly injections directly into their tumors. A total of 284 CT-guided injections were performed.

In every case, the UCLA team successfully placed the needle and injected the agent into the tumor. None of the patients experienced serious adverse effects. Minor complications occurred in 14.8 percent of injections. The most common complication was air collection in the chest, for which only one patient required drainage. The complication rate did not increase with the number of injections.

"Our findings validate that CT-guided injection and delivery of gene therapy agents is both feasible and safe," said Dr. Suh.



"Metastatic Renal Cell Carcinoma: CT-guided Immunotherapy as a Technically Feasible and Safe Approach to Delivery of Gene Therapy for Treatment." Collaborating with Dr. Suh on this paper were Jonathan G. Goldin, M.D., Amanda B. Wallace, B.S., Ramon E. Sheehan, M.D., Stefan B. Heinze, M.D., Barbara J. Gitlitz, M.D., and Robert A. Figlin, M.D.

Maureen Morley | EurekAlert!
Further information:
http://www.rsna.org
http://radiology.rsnajnls.org

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Hubble captures massive dead disk galaxy that challenges theories of galaxy evolution

22.06.2017 | Physics and Astronomy

New femto-camera with quadrillion fractions of a second resolution

22.06.2017 | Physics and Astronomy

Rice U. chemists create 3-D printed graphene foam

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>