Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Understanding epilepsy

27.04.2004


Misconceptions hinder treatment



For nearly three thousand years, people believed that epilepsy had a supernatural cause. But the most dangerous misconception about epilepsy is a modern one, according to epilepsy expert Jerome Engel, Jr., M.D., Ph.D.--many people, including physicians, still believe that epilepsy can’t be treated.

"Epilepsy and epileptic seizures are far more common than people realize," said Dr. Engel, Jonathan Sinay Professor of Neurology and Neurobiology at the David Geffen School of Medicine at UCLA, chief of epilepsy and clinical neurophysiology at the UCLA Center for the Health Sciences and director of the UCLA Seizure Disorder Center, Reed Neurological Research Center, Los Angeles.


Dr. Engel spoke today at an American Medical Association media briefing in partnership with the American Academy of Neurology (AAN) and the American Epilepsy Society at the AAN’s annual meeting in San Francisco.

Epileptic seizures are a sign of brain dysfunction. "A very simple way to explain a seizure might be as overactivity in the brain, often, though not always, the result of an injury," he said. "Epilepsy is the chronic condition that results when these brain disturbances persist. Early diagnosis and treatment are vital, because seizures should be stopped before the patient suffers irreversible damage."

Forty million people worldwide have epilepsy. Five to 10 percent of the U.S. population will have a seizure during their lifetime and of those, 30 percent will develop epilepsy. The burden of this disease, however, can’t be understood simply through the numbers, according to Dr. Engel.

"Uncontrolled epilepsy presents an enormous personal burden," said Dr. Engel. "Seizures happen without warning and are frightening and embarrassing; they can result in accidental injury or even death. Imagine the restrictions this places on an active life. A person with epilepsy can’t drive a car, hold certain jobs, or participate fully in recreational activities."

"This is a disease that strikes the young, often children," Dr. Engel said. "This means years and years of disability, lost years of good quality of life and lost earnings. When these elements are factored in, the impact of epilepsy worldwide is equal to the impact of breast cancer in women and lung cancer in men."

The restrictions on daily activity and years of disability would be bad enough, but they are made worse by the stigma that is still attached to epilepsy. "Even today a surprising number of people believe epilepsy is supernatural, caused by possession," said Dr. Engel. "Many people still believe that epilepsy is a psychiatric disorder or mental retardation. An editorial in the British Medical Journal recently put it well: "The history of epilepsy is 3000 years of ignorance, stigma, and discrimination and 100 years of knowledge, stigma, and discrimination."

The most destructive misperception about epilepsy is that it can’t be effectively treated. "Even physicians often believe that seizures can’t be stopped, leading to treatment delays that can result in preventable, irreversible disability," said Dr. Engel. "Our treatment objectives should be no seizures, no side effects and the earliest possible intervention."

Guidelines can have an enormous impact on treatment by educating physicians and directing research goals. "Last year, the American Academy of Neurology introduced guidelines stating that surgical treatment for temporal lobe epilepsy is effective, but did not answer the question of how quickly it should be considered’," said Dr. Engel. "Their recommendation has resulted in the National Institute of Neurological Disorders and Stroke (NINDS) committing $30 million dollars for the Early Randomized Surgical Epilepsy Trial (ERSET) to address this issue."


Media Advisory: To contact Jerome Engel, Jr., M.D., Ph.D., contact Dan Page at 310-794-0777 or dpage@support.ucla.edu. On the day of the briefing, call the AMA’s Science News Department at 312-464-2410, the AAN Press Room at 415-978-3521 or email kstone@aan.com.

Dan Page | EurekAlert!
Further information:
http://www.ama-assn.org/

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>