Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Improving the chances of successful organ transplants

15.04.2004


Each year over 50,000 patients undergo life-saving kidney, liver, or heart and lung transplant surgery. Unfortunately, organ transplantation remains a significant challenge because of the shortage of organ donors and differences in tissue type between donor and recipient that can cause rejection of the donor organ by the recipient’s immune system. If this rejection reaction is not successfully treated through the administration of immunosuppressive drugs, the donor organ is normally destroyed within a short period of time.



EUREKA project E! 2674 MIDAS (Medical Diagnostics Applied to Surgery) has developed a new test that can significantly improve graft survival by finding a more accurate organ match.

“Usually organs are matched to recipients by comparing tissue types and selecting those pairings with the smallest genetic mismatch. Using this method alone, however, ignores sensitisation which can turn a slight mismatch into an unacceptably high risk,” explains Dr Nikolai Schwabe, CEO of UK lead partner ProImmune and the overall co-ordinator of the project.


“Sensitisation can occur as a consequence of prior contact by the recipient with the foreign tissue type, such as previous transplantations, blood transfusions and especially, in women, pregnancies during which women can be exposed to the father’s tissue type via the blood of their child. Our test is able to detect the degree of sensitisation with unprecedented accuracy and should eventually become a universal standard in testing for organ compatibility in transplant surgery,” says Dr Schwabe.

The MIDAS project was based on work that had won ProImmune a DTI SMART award and was continued within EUREKA. “This project brought us a significant step closer to entering a new and very promising product area, and it would not have been possible without the help of the EUREKA scheme,” explains Dr Schwabe. “In my mind, the EUREKA scheme stands out from other funding mechanisms, because of its flexibility. Projects are selected on the basis of their overall merit as judged by experts, in a process that is non-bureaucratic and efficient.”

With 100,000 patients on waiting lists each year, the global market for the MIDAS test could be as big as € 50 million per year. Negotiations are underway to commercialise the project through a partnership with a leading company in the area of transplantation diagnostics.

“The market in transplantation diagnostics is quite entrenched, with a few big companies dominating the field. It became clear that we should work with a market leader to successfully commercialise the MIDAS test,” explains Dr Schwabe.

Julie Sors | Eureka
Further information:
http://www.eureka.be/success-stories

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>