Each year over 50,000 patients undergo life-saving kidney, liver, or heart and lung transplant surgery. Unfortunately, organ transplantation remains a significant challenge because of the shortage of organ donors and differences in tissue type between donor and recipient that can cause rejection of the donor organ by the recipients immune system. If this rejection reaction is not successfully treated through the administration of immunosuppressive drugs, the donor organ is normally destroyed within a short period of time.
EUREKA project E! 2674 MIDAS (Medical Diagnostics Applied to Surgery) has developed a new test that can significantly improve graft survival by finding a more accurate organ match.
“Usually organs are matched to recipients by comparing tissue types and selecting those pairings with the smallest genetic mismatch. Using this method alone, however, ignores sensitisation which can turn a slight mismatch into an unacceptably high risk,” explains Dr Nikolai Schwabe, CEO of UK lead partner ProImmune and the overall co-ordinator of the project.
Julie Sors | Eureka
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