Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biosensor-regulated gene therapy reduces heart attack damage in mice

07.04.2004


A novel gene therapy that responds specifically to oxygen-starved heart muscle may protect against further injury following a heart attack, a study by University of South Florida cardiovascular researchers found.



Their findings are reported in the April 2004 issue of the journal Hypertension.

M. Ian Phillips, PhD, DSc, and his team at the USF College of Medicine and All Children’s Hospital Research Institute designed a kind of oxygen-sensitive biosensor that turns on protective genes when signs of oxygen deprivation indicate a heart attack and turns the genes off once blood flow restores adequate oxygen levels to the heart. Dr. Phillips, principal investigator; Yao Liang Tang, MD, lead author; and colleagues showed that this biosensor-regulated gene therapy protected heart muscle cells in mice with heart attacks from further injury.


Dr. Phillips and Dr. Tang envision administering such a therapy after a first heart attack to limit initial damage and prevent future attacks. While much work remains to test and refine such a therapy, Dr. Phillips said, this new concept might eventually be an alternative to stents and bypass surgery.

People who suffer one heart attack are at higher risk for subsequent attacks. Often lack of blood flow to the heart muscle, known as cardiac ischemia, does not cause pain or other symptoms. This asymptomatic or "silent" ischemia can lead to a second or third heart attack without prior warning.

"Repeated bouts of myocardial ischemia cause cumulative tissue damage in the heart vessels that can lead to a fatal heart attack," said Dr. Phillips, USF vice president for research and professor of physiology and biophysics. "Therefore, what patients need is a gene therapy strategy that acts in the heart and switches on or off, so that the therapeutic protein is produced only where and when it is needed."

"One of the exciting aspects of the approach, described by Tang et al, is the ability to directly link expression of potentially therapeutic genes to a pathological stimulus associated with myocardial infarction, ischemia," states an editorial in Hypertension highlighting the USF research. "Ultimately, this area of research will pave the way for development of ’smart’ therapies for the heart that allow for early and rapid treatment of a wide variety of cardiac ailments."

The USF researchers designed a molecule -- which they call a "vigilant vector" -- containing both a means to increase the expression of protective heme oxygenase-1(HO-1) genes and the oxygen-sensitive switch that turns these genes on and off. They injected this molecule directly into the hearts of mice one hour after the mice had heart attacks.

Ten days following their heart attacks, the mice that received the biosensor-regulated gene therapy showed less heart tissue scarring and better recovery of heart pumping function than the untreated mice injected with saline only. The researchers demonstrated that turning on the protective HO-1 genes stopped the heart muscle cells from dying and limited the area of damage.

Anne DeLotto Baier | EurekAlert!
Further information:
http://hsc.usf.edu/

More articles from Health and Medicine:

nachricht Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>