Researchers from Finland have found that the antidepressant drug fluvoxamine (brand names Fevarin, Faverin, Luvox etc.) drastically increases the concentrations of tizanidine (Sirdalud, Zanaflex) in blood.
Concomitant use of fluvoxamine and tizanidine results in severe and prolonged decrease in blood pressure and greatly enhanced central nervous system effects. This previously unrecognised interaction can be dangerous, particularly in elderly patients, and the concomitant use of the two agents must be avoided. Both fluvoxamine and tizanidine have been in wide clinical use for more than 10 years.
The concentrations of tizanidine in blood were increased on average 33-fold by fluvoxamine in a carefully controlled study in healthy volunteer subjects. The volunteers ingested the usual 100-mg dose of fluvoxamine or placebo daily for 4 days, and then a single 4-mg dose of tizanidine. The interaction was observed in each of the ten subjects; the smallest increase in tizanidine concentration by fluvoxamine was 14-fold, the greatest increase was 103-fold!
Paivi Lehtinen | alfa
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