Researchers from Finland have found that the antidepressant drug fluvoxamine (brand names Fevarin, Faverin, Luvox etc.) drastically increases the concentrations of tizanidine (Sirdalud, Zanaflex) in blood.
Concomitant use of fluvoxamine and tizanidine results in severe and prolonged decrease in blood pressure and greatly enhanced central nervous system effects. This previously unrecognised interaction can be dangerous, particularly in elderly patients, and the concomitant use of the two agents must be avoided. Both fluvoxamine and tizanidine have been in wide clinical use for more than 10 years.
The concentrations of tizanidine in blood were increased on average 33-fold by fluvoxamine in a carefully controlled study in healthy volunteer subjects. The volunteers ingested the usual 100-mg dose of fluvoxamine or placebo daily for 4 days, and then a single 4-mg dose of tizanidine. The interaction was observed in each of the ten subjects; the smallest increase in tizanidine concentration by fluvoxamine was 14-fold, the greatest increase was 103-fold!
Paivi Lehtinen | alfa
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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