Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


ERI patents treatments for insulin resistance in diabetes accompanying obesity


Dr. Miles Brennan of the Eleanor Roosevelt Institute at the University of Denver (ERI) and Dr. Ute Hochgeschwender of the Oklahoma Medical Research Foundation have patented a method of reducing insulin resistance that could lead to potential treatments for diabetes accompanying obesity.

Insulin is a hormone that prompts cells to store glucose, a natural sugar, while another hormone called glucagon has the opposite effect, prompting cells to release stored glucose into the bloodstream. In healthy individuals the two hormones achieve homeostasis, or balance. Type II diabetes occurs when the body becomes resistant to insulin, preventing it from storing glucose. Because melanocyte-stimulating hormone (MSH) causes the pancreas to secrete glucagon, MSH must be present for type II diabetes to develop. Obesity and high cholesterol are risk factors for the disease, which leads to high blood pressure, strokes, heart attacks, blindness, kidney failure and possible amputation of the lower extremities.

The new process, which is described in U.S. Patent #6,689,938, is for treatment of diabetes by administering an antagonist of MSH. The patent covers the use of a whole class of MSH antagonists, chemicals that either remove the hormone from the system or which block the action of MSH in the bloodstream.

"Because type II diabetes is essentially an insensitivity to insulin action, we can now circumvent this resistance by working on the glucagon half of the circuit," explains Brennan. "If you’re insensitive to insulin, this approach may be able to bring you back into homeostasis by decreasing glucagon in the bloodstream."

Previous treatments for type II diabetes have focused on altering the amount of glucose in the bloodstream. Brennan and Hochgeschwender instead focused on regulating insulin resistance in genetically engineered mice by manipulating the amount of MSH in the bloodstream.

"It’s a whole new way of looking at diabetes," says Brennan. "People have been working on diabetes for years, and this is an entirely unexpected departure, both in understanding how diabetes works and also in treating it."

The patent also includes a method for identifying compounds useful for reducing insulin resistance in a patient with obesity or type II diabetes. That process works by administering a peptide compound with MSH to genetically engineered mice with a modified POMC gene, which is responsible for manufacturing MSH.

Administering different MSH compounds to mice with different modifications to the POMC gene stimulates the secretion of various other hormones, which can be further studied for their roles in insulin resistance. Another patent issued to the same inventors covers mice with a range of genetic modifications to the POMC gene. The genetic modifications create obese mice that, surprisingly, do not develop diabetes.

Denver’s Eleanor Roosevelt Institute (ERI) was founded in 1961 as a private, independent research center. ERI merged with the University of Denver in 2003. The Institute is staffed by leading scientists from around the world who study Down syndrome, Lou Gehrig’s disease, cancer, obesity, type II diabetes and other diseases and conditions. It is the mission of the Institute’s scientists to seek an in-depth understanding of the process of life and through this understanding, work towards unlocking the mysteries of human health and disease.

Warren Smith | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>