Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers say stenting the best treatment for blocked leg arteries

30.03.2004


Researchers at Brown Medical School in Providence, R.I., have reported that stent placement should be considered the standard of care for treating patients with abnormal circulation, or "ischemia" to the legs, due to obstruction of the iliac arteries. The iliac arteries are large arteries in the pelvis that supply blood to the legs. The study appears in the April issue of the journal Radiology.



Lower-extremity ischemia, a type of peripheral vascular disease (PVD), occurs when arteries in the abdomen or pelvis, called the aorta and iliac arteries, respectively, narrow or become completely blocked by the build-up of atherosclerotic plaque deposits. As a result, not enough oxygen-rich blood gets to the legs, causing cramps and pain and making it difficult to walk or exercise. Rarely, the condition becomes so severe that gangrene develops or amputation of the affected limb is necessary.

Until the introduction of the stent, a small metal tube, 10 years ago, the only way to open up such vessels was surgically, bypassing the blockage with a healthy vein or artery.


Increasingly, interventional radiologists are treating the condition with a less invasive stenting procedure, in which a catheter-or thin, flexible tube-is inserted through a small incision in the skin and threaded to the site of the blocked artery. The vessel is pumped open by a tiny balloon, and the stent is inserted to hold open the blood vessel.

"The early results of stent placement suggested that it offered excellent short-term results for treating this condition," said lead researcher Timothy P. Murphy, M.D., associate professor of diagnostic imaging at Brown Medical School. "But long-term results were needed to prove that the stent is a viable treatment option for this type of peripheral vascular disease."

Dr. Murphy and a team of researchers reviewed the records of 365 patients suffering from chronic leg ischemia. Between 1992 and 2001, stents were placed in the patients’ iliac arteries to treat 505 arterial build-ups, or lesions. Of those lesions, 88 were complete blockages and 417 were significantly narrowed vessels. Researchers analyzed clinical patient data for up to eight years after stent placement.

Of the 496 limbs for which follow-up data were available, improved blood circulation was achieved in 484 limbs, for a success rate of 98 percent. After five years, 86 percent of stented vessels remained open; after eight years, 84 percent did. Those rates are comparable to published results for femoral artery bypass surgery, which has a five- to 10-year success rate of between 80 percent and 91 percent.

The mortality rate for the stent-placement procedure is a key finding of the Brown Medical School study. The 30-day mortality rate for stent placement was 0.5 percent. In comparison, the published 30-day mortality rate for femoral artery bypass surgery since 1993 is 3.3 percent.

"It’s clear that the long-term clinical results of stent placement are comparable to those of femoral artery bypass surgery, with a much lower risk of associated morbidity and mortality," Dr. Murphy said. "Stent placement for the treatment of lower extremity ischemia is simply better tolerated by patients, with better results."



Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America, Inc. (http://radiology.rsnajnls.org)

The Radiological Society of North America is an association of more than 35,000 radiologists, radiation oncologists and related scientists committed to promoting excellence in radiology through education and by fostering research, with the ultimate goal of improving patient care. The Society is based in Oak Brook, Ill. (http://www.rsna.org)

"Aortoiliac Insufficiency: Long-term Experience with Stent Placement for Treatment." Nikki S. Ariaratnam, B.A., Wilfred I. Carney, Jr., M.D., Edward J. Marcaccio, M.D., Jeffrey M. Slaiby, M.D., Gregory M. Soares, M.D., and H. Myra Kim, Sc.D., collaborated with Dr. Murphy on this paper.

Maureen Morley | EurekAlert!
Further information:
http://radiology.rsnajnls.org
http://www.rsna.org

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Structured light and nanomaterials open new ways to tailor light at the nanoscale

23.04.2018 | Physics and Astronomy

On the shape of the 'petal' for the dissipation curve

23.04.2018 | Physics and Astronomy

Clean and Efficient – Fraunhofer ISE Presents Hydrogen Technologies at the HANNOVER MESSE 2018

23.04.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>