Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of T researchers one step closer to creating oral insulin

29.03.2004


University of Toronto researchers have shown that "designer molecules" can interact with the body’s insulin receptor, a step toward the development of an oral medication for diabetes.



U of T professors Lakshmi Kotra, Cecil Yip, Peter Ottensmeyer and Robert Batey have created the first small molecules using the three-dimensional structure of the insulin receptor. A receptor is the site on the surface of a cell to which molecules with specific tasks, such as hormones, attach themselves. Insulin’s task is to initiate the utilization of sugar in the blood.

"This is the first time that a 3-D model of the insulin receptor on a cell surface has been created and used for drug design," says Kotra, director of U of T’s Molecular Design and Information Technology Centre (MDIT). The study appears in the March 22 issue of Bioorganic & Medicinal Chemistry Letters.


The 3-D computer modelling of the receptor and the drug design were conducted at MDIT, a state-of-the-art computer modelling centre with resources for drug design. Researchers then used this knowledge to create specially-designed molecules that bind to the receptor in the same way insulin does. In so doing, they hope to develop a drug similar to insulin that can be taken orally. (Insulin itself must be injected directly into the bloodstream because it is broken down in the stomach if taken orally.)

More than two million Canadians have diabetes, and many of them require regular insulin injections to help their bodies absorb sugar properly. Research has shown self-injection to be a problem for children and the elderly, and lifelong regular injections are not pleasant for patients.

Previous efforts to create oral medications with insulin’s properties have failed, due to inadequate knowledge of the dynamics of the relationship between insulin and its receptor. Since the U of T team now understands this structural relationship, they can work to design novel molecules that mimic insulin’s therapeutic properties.

Other researchers included Ira Goldfine of the University of California, San Francisco, and U of T postdoctoral fellows Christopher Tan and Lianhu Wei. U of T Innovations Foundation is managing the commercialization of this discovery. This research is supported by Canadian Institutes of Health Research, Proof-of-Principle programs.

Elaine Smith | University of Toronto
Further information:
http://www.news.utoronto.ca/bin5/040326a.asp

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>