Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of T researchers one step closer to creating oral insulin

29.03.2004


University of Toronto researchers have shown that "designer molecules" can interact with the body’s insulin receptor, a step toward the development of an oral medication for diabetes.



U of T professors Lakshmi Kotra, Cecil Yip, Peter Ottensmeyer and Robert Batey have created the first small molecules using the three-dimensional structure of the insulin receptor. A receptor is the site on the surface of a cell to which molecules with specific tasks, such as hormones, attach themselves. Insulin’s task is to initiate the utilization of sugar in the blood.

"This is the first time that a 3-D model of the insulin receptor on a cell surface has been created and used for drug design," says Kotra, director of U of T’s Molecular Design and Information Technology Centre (MDIT). The study appears in the March 22 issue of Bioorganic & Medicinal Chemistry Letters.


The 3-D computer modelling of the receptor and the drug design were conducted at MDIT, a state-of-the-art computer modelling centre with resources for drug design. Researchers then used this knowledge to create specially-designed molecules that bind to the receptor in the same way insulin does. In so doing, they hope to develop a drug similar to insulin that can be taken orally. (Insulin itself must be injected directly into the bloodstream because it is broken down in the stomach if taken orally.)

More than two million Canadians have diabetes, and many of them require regular insulin injections to help their bodies absorb sugar properly. Research has shown self-injection to be a problem for children and the elderly, and lifelong regular injections are not pleasant for patients.

Previous efforts to create oral medications with insulin’s properties have failed, due to inadequate knowledge of the dynamics of the relationship between insulin and its receptor. Since the U of T team now understands this structural relationship, they can work to design novel molecules that mimic insulin’s therapeutic properties.

Other researchers included Ira Goldfine of the University of California, San Francisco, and U of T postdoctoral fellows Christopher Tan and Lianhu Wei. U of T Innovations Foundation is managing the commercialization of this discovery. This research is supported by Canadian Institutes of Health Research, Proof-of-Principle programs.

Elaine Smith | University of Toronto
Further information:
http://www.news.utoronto.ca/bin5/040326a.asp

More articles from Health and Medicine:

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

nachricht Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>