Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tadpoles and tumors

29.03.2004


A protein critical in tadpole metamorphosis has role in human cancer



There’s something magical about tadpoles. The mere mention of this little creature sparks happy memories of children screaming with delight as they splash in a shallow stream trying to capture some of the tiny swimmers in a cup. The real magic happens as the children witness the metamorphosis from tadpole to frog.

Within the mystery of this transformation is a biological series of changes that among other things, allows one appendage to be shed while four others sprout from the tadpole’s body. Before a tadpole becomes a frog, it must lose its tail. A time-lapse video of this process would actually reveal that the tadpole tail doesn’t simply fall off but rather grows shorter in a process called tail resorption.


Scientists who study this process on a molecular level have known that a protein called FAP (fibroblast activation protein) is involved in tail resorption. However, FAP may have a much more perverse role in humans.

"We know that FAP helps control the breakdown of the extracellular matrix that allows tadpole tail resorption, and we believe that the same type of activity has to happen for tumor growth," said Jonathan D. Cheng, M.D., a medical oncologist and researcher at Fox Chase Cancer Center. "We are currently investigating how the two may be related biologically.

"Animal studies have shown that producing lots of FAP in the tumor’s microenvironment makes the cancer grow faster. We are now learning more about how FAP does that."

In a study presented today at the 95th Annual Meeting of the American Association for Cancer Research in Orlando, Fla., Cheng and his colleagues demonstrate that the enzymatic activity of FAP is responsible for the accelerated tumor growth in mice. Cheng’s research also examines the ability of an antibody molecule to stop the enzymatic activity of FAP.

"We know that FAP is present in about 90 percent of human solid malignancies, so that makes this protein a target well worth pursuing," Cheng said. "Antibodies have an inherent advantage in that they can specifically target FAP and not other proteins. Although the antibody we have studied so far has had only modest results to date, we are making some modifications to our existing antibodies to improve the molecule’s ability to block FAP’s action. Much more research lies ahead."


Fox Chase Cancer Center, one of the nation’s first comprehensive cancer centers designated by the National Cancer Institute in 1974, conducts basic, clinical, population and translational research; programs of prevention, detection and treatment of cancer; and community outreach. For more information about Fox Chase activities, visit the Center’s web site at http://www.fccc.edu or call 1-888-FOX CHASE.

Karen Carter Mallet | EurekAlert!
Further information:
http://www.fccc.edu

More articles from Health and Medicine:

nachricht Observing the cell's protein factories during self-assembly
15.06.2018 | Charité - Universitätsmedizin Berlin

nachricht Scientists unravel molecular mechanisms of Parkinson's disease
13.06.2018 | The Francis Crick Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive

15.06.2018 | Materials Sciences

100 % Organic Farming in Bhutan – a Realistic Target?

15.06.2018 | Ecology, The Environment and Conservation

Perovskite-silicon solar cell research collaboration hits 25.2% efficiency

15.06.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>