Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An alternative to bone-marrow donation

29.03.2004


Researchers have developed a method to reconstitute bone marrow and blood cells from embryonic stem (ES) cells. As reported in The Journal of Experimental Medicine, this method was effective even in genetically mismatched mice. If the same is true in humans, this would remove the need to find genetically matched human bone-marrow donors for patients with leukemia, immune deficiencies and autoimmune diseases.



ES cells are cells derived from embryos that have the potential to grow into many different cell types. Richard Burt and colleagues identified the most effective mix of growth factors to induce mouse ES cell lines to develop into bone-marrow and blood precursor cells in culture. They also devised a method to select the best cells from these cultures. Injection of the selected cells into the bone marrow of mice that had been depleted of their own bone-marrow cells resulted in restoration of blood cells, including cells of the immune system, which are normally produced in the bone marrow.

Despite the genetic mismatch between donor and recipient, the injected cells were not rejected. This is consistent with previous evidence that ES cells are somehow less susceptible than adult cells to being identified as foreign by the immune system. The basis of this difference is not understood.


There was also no evidence that the immune cells derived from ES cells were attacking the recipient. The equivalent process after bone marrow transplantation is an often fatal complication known as graft-versus-host disease. The immune response to foreign antigens was, however, normal, indicating that recipients would be able to fight off infection efficiently.

Although the use of ES cell lines is controversial, it has many potential advantages over the use of cells from donor bone marrow or blood. The latter cells are highly variable, cannot be cultured in the lab and often cause graft-versus-host disease. Human ES cell lines can be cultured indefinitely, providing a renewable and well-defined source that is free from bacterial contamination.


Contact: Dr Richard Burt, Northwestern University, Chicago, 312-908-0059, rburt@nwu.edu

Lynette Henry | EurekAlert!
Further information:
http://www.rupress.org/

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>