Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An alternative to bone-marrow donation

29.03.2004


Researchers have developed a method to reconstitute bone marrow and blood cells from embryonic stem (ES) cells. As reported in The Journal of Experimental Medicine, this method was effective even in genetically mismatched mice. If the same is true in humans, this would remove the need to find genetically matched human bone-marrow donors for patients with leukemia, immune deficiencies and autoimmune diseases.



ES cells are cells derived from embryos that have the potential to grow into many different cell types. Richard Burt and colleagues identified the most effective mix of growth factors to induce mouse ES cell lines to develop into bone-marrow and blood precursor cells in culture. They also devised a method to select the best cells from these cultures. Injection of the selected cells into the bone marrow of mice that had been depleted of their own bone-marrow cells resulted in restoration of blood cells, including cells of the immune system, which are normally produced in the bone marrow.

Despite the genetic mismatch between donor and recipient, the injected cells were not rejected. This is consistent with previous evidence that ES cells are somehow less susceptible than adult cells to being identified as foreign by the immune system. The basis of this difference is not understood.


There was also no evidence that the immune cells derived from ES cells were attacking the recipient. The equivalent process after bone marrow transplantation is an often fatal complication known as graft-versus-host disease. The immune response to foreign antigens was, however, normal, indicating that recipients would be able to fight off infection efficiently.

Although the use of ES cell lines is controversial, it has many potential advantages over the use of cells from donor bone marrow or blood. The latter cells are highly variable, cannot be cultured in the lab and often cause graft-versus-host disease. Human ES cell lines can be cultured indefinitely, providing a renewable and well-defined source that is free from bacterial contamination.


Contact: Dr Richard Burt, Northwestern University, Chicago, 312-908-0059, rburt@nwu.edu

Lynette Henry | EurekAlert!
Further information:
http://www.rupress.org/

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>