Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new gene for familial cancer was found

26.03.2004


A research group at the University of Helsinki, Finland, has found a gene defect that causes hereditary colorectal cancer and defects in dentition. The finding was published online on March 23 in the American Journal of Human Genetics.



The groups led by professors Sinikka Pirinen and Irma Thesleff at the Institute of Dentistry and Institute of Biotechnology of the University of Helsinki are working on the genetic basis of hereditary dental aberrations .

The group identified a mutation in the gene AXIN2 in a Finnish family with severe lack of teeth. AXIN2 is known as a modulator of Wnt signalling which is one of the key signal pathways regulating embryonic development. The specific roles of AXIN2 during development have, however, not been known, and its essential role for the development of teeth was also previously unknown.


Congenital absence of a few teeth is rather common and it is usually not associated with any other health problem. However, in this family the individuals who lacked teeth were also diagnosed to have neoplastic changes in the colon. The neoplasias ranged from polyps to precancerous lesions and cancer. Those members of the family who did not have the mutation did neither have defects in teeth nor neoplastic changes in colon.

The patients who had the mutation lacked 8 to 27 permanent teeth, thus in the most severe cases almost all permanent teeth were missing. Defects in the deciduous dentition were observed in only one patient. A different mutation in AXIN2 was found in an unrelated patient who also lacked several permanent teeth.

It is interesting that one gene mutation causes both tooth agenesis and predisposes to colorectal cancer. The finding underlines the concept that same genes act in normal and malignant development.

On the other hand, the connection between tooth agenesis and cancer raises the question whether tooth agenesis could be used as an indication for cancer susceptibility. The results so far show that mutations in AXIN2 are responsible for only a small proportion of tooth agenesis, and that they may be limited to severe forms. The researchers now plan to evaluate the existence of the connection between tooth agenesis and cancer on a population level.

More information: Pekka Nieminen, tel. +358 -9-19125215,
e-mail: pekka.nieminen@helsinki.fi

Paivi Lehtinen | alfa
Further information:
http://www.helsinki.fi/science/dentgen

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>