Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HIV-infected have thicker carotid artery walls - predictor of heart attack & stroke

19.03.2004


With the advent of antiretroviral medication, HIV patients are living longer and facing yet another health challenge.



Carotid artery intima-media thickness (IMT) - a potent predictor of heart attack and stroke - is significantly higher in HIV-infected patients compared to uninfected controls, according to study results from UCSF researchers. In addition after one year of follow-up, carotid artery IMT progressed significantly faster in HIV-infected individuals.

"Our findings suggest that it would be reasonable to consider HIV infection a cardiac risk factor. Other risk factors, such as high cholesterol and high blood pressure need to be aggressively treated in HIV patients - even it if means changes in their HIV medications." said the study’s lead author, Priscilla Hsue, MD, assistant professor of medicine at UCSF.


The study, published in the April 6th issue of Circulation, found that HIV infection was an independent predictor of carotid artery IMT along with age, LDL-cholesterol levels, and cigarette smoking. Duration of protease inhibitor therapy was not associated with thicker carotid IMT.

Carotid IMT progression over one year was greater among the 121 HIV patients with follow-up measurements. IMT progression was associated with older age, Latino race, and a history of a low CD4 cell count.

In order to address cardiovascular issues in HIV patients, Hsue is opening one of the first cardiac sub-specialty clinics for HIV patients at the UCSF Positive Health Program based at San Francisco General Hospital Medical Center (SFGHMC).

"The greater rate of progression in arterial thickening among HIV patients is a cause for concern because it indicates that these patients could experience more vascular events in the future. Our primary motivation for starting a cardiac specialty clinic was to address cardiac issues and risk factors in HIV patients and to try and prevent cardiac complications before they occur," said Hsue.


Study co-authors are Joan C. Lo, MD, UCSF assistant adjunct professor of medicine at the General Clinical Research Center; Arlana Franklin, RDMS, UCSF senior technologist; Ann F. Bolger, MD, UCSF associate professor of clinical medicine; Steven G. Deeks, MD, UCSF associate professor of clinical medicine at the Positive Health Program; and David D. Waters, MD, UCSF professor of medicine, all at SFGHMC; and Jeffrey N. Martin, MD, MPH, UCSF assistant professor in the Department of Epidemiology and Biostatistics.

The study was conducted at the General Clinical Research Center at SFGHMC. It was funded by grants from the Doris Duke Charitable Foundation, the National Institutes of Health, the California AIDS Research Center, the UCSF Academic Senate, the UCSF/Gladstone Institute for Virology and Immunology Center for AIDS Research, and Astra Zeneca.

Jeff Sheehy | EurekAlert!
Further information:
http://www.ucsf.edu/

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>