Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Innovative reconstructive surgery improves appearance, outcomes for skin cancer patients

05.03.2004


OHSU study finds patients with massive skin cancers improve overall quality of life after free tissue transfer surgery



Dorothy Fahland says she was as a typical blue-eyed blonde with freckles growing up on Long Island, N.Y. She spent her days playing on the beach and sailing with friends. "No one ever thought to wear sunscreen back then," she said. "As a teenager, the goal was to get as tan as possible, so I was in the sun a lot."

Today Fahland, 72, of Olympia, Wash., regrets having spent her youth basking unprotected in the sun’s harmful rays. She is one of 250,000 Americans each year who develop a form of skin cancer called squamous cell carcinoma. If caught early, squamous cell carcinoma typically doesn’t spread, but if neglected or undiscovered for years, it can spread to other parts of the body, causing significant disfigurement and even death.


Fahland’s battle with skin cancer began in 1997 with a cancerous lesion above her eye. Her cancer was removed and treated, and Dorothy underwent annual CT scans for the next four years. It was during her July 2001 scan that a tumor was discovered behind her eye. "Unbeknownst to me the cancer had traveled along the optic nerve," Dorothy said. "I was told from the beginning I would lose my eye."

"Most head and neck cancers can easily be removed and treated by a facial plastic surgeon," Mark Wax, M.D., professor of otolaryngology/head and neck surgery in the Oregon Health & Science University School of Medicine. "But some skin cancers that have recurred after multiple treatments, or that have grown to great size due to neglect require removal of massive amounts of tissue, leaving the patient with a large defect that is difficult to reconstruct with surrounding tissue."

After being told she would lose her eye, Fahland searched the Internet for a "surgical team that would provide the best chance of survival and the best appearance." Her efforts led her to Wax and his colleague Peter Andersen, M.D., who proposed she undergo skin cancer free tissue transfer.

"Free tissue transfer has revolutionized the care of the patient with massive skin cancer," said Wax. "A few years ago, patients with massive skin cancers were left with huge holes and told ’that’s as good as it gets.’ Now, with this technique, patients are once again able to talk, eat and breathe easier. More importantly, their quality of life is better. They’re willing to go out and do things with their families."

Free tissue transfer for skin cancer involves transferring muscle and blood vessels from one part of the body to another to reconstruct damaged or missing tissue. Although free tissue transfer surgery has been around since 1991, only a few surgeons perform this type of reconstruction. OHSU is the only center in Oregon to offer this expertise.

Wax and his colleagues recently published a study showing that patients requiring major removal of head and neck tissue -- skin, eye, ear, lip, nose and cheek tissue -- experienced significant improvement in function, appearance and quality of life, as well as excellent survival rates following surgery using free tissue transfer.

The researchers reviewed the charts of 43 patients (38 men and five women) who were treated for massive neglected skin cancers of the cheek, ear, forehead, neck, scalp and nose at OHSU, Vanderbilt University or West Virginia University from January 1992 through October 2001. The study was published in the Archives of Facial Plastic Surgery.

According to Wax, principal investigator for the study, the only option previously available to these patients were prostheses. "Facial prosthetics can be excellent, but not all patients have access or can afford the time and expense involved in getting them," he explained.

Andersen, an associate professor of otolaryngology/head and neck surgery in the OHSU School of Medicine, removed Fahland’s eye and surrounding tissue in 2001, and Wax replaced them with muscle and blood vessels from her abdomen. Today she is living an active, cancer-free life.

"I was told I would be left with a good appearance, and I’m pleased with the results. I’ve adjusted to having one eye very well, although I do have to be careful with steps, stairs and curbs. Six months after the surgery, I passed a driving test with one eye. I remain healthy with good nutrition and exercise and the support of my husband, Frank."

SQUAMOUS CELL CARCINOMA FACTS

Squamous cell carcinoma is the second most common form of skin cancer. Middle-aged and elderly people who have experienced excessive, chronic sun exposure for many years, and people with white skin, especially those with blonde or red hair, are particularly susceptible, according to the American Academy of Dermatology.

To prevent squamous cell carcinoma, dermatologists recommend wearing suncreen with SPF 15 or higher and a wide-brimmed hat whenever spending time, even briefly, in the sun.

Tamara Hargens | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>