Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Study Reviews Novel Approach To Control Inflammation Using Melanocortin Receptors

04.03.2004


Study Supports Development Potential in Several Therapeutic Areas

Zengen, Inc. announced today that its researchers have discovered that activation of melanocortin receptors (MCR) subtypes MC1R and MC3R could be a novel strategy to control inflammatory disorders.

The findings, "Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation," appear in the March 2004 issue of Pharmacological Reviews, a publication of the American Society for Pharmacology and Experimental Therapeutics (ASPET).

"MCR activation causes a collective reduction of the major molecules involved in the inflammatory process," said Anna Catania, M.D., professor of endocrinology, School of Internal Medicine, University of Milan and lead author of the study. "This discovery is significant because it shows that treatment with melanocortin peptides doesn’t abolish the inflammatory response but instead modulates it. An advantage of melanocortins in the treatment of inflammation is that their influences are broad and are not restricted to a specific mediator or chemical pathway."

Recognition and cloning of five melanocortin receptors has greatly improved understanding of peptide-target cell interactions. Preclinical investigations indicate that activation of certain MCR subtypes, primarily MC1R and MC3R, could be useful in treatment of localized and systemic inflammatory disorders. These include: organ transplantation, chronic inflammatory diseases, acute inflammation, inflammation within the brain and neurogenerative disorders, peripheral neuropathies, systemic host reactions, ischemia and reperfusion injury and infections.

"The study results also indicate that certain melanocortin peptides have antimicrobial effects," said James Lipton, Ph.D., chief scientific officer and director of Zengen and study author. "Unlike corticosteroids, melanocortins do not reduce microbial killing activity, but enhance it. We are encouraged by these findings and will continue our research and development efforts in peptide technology."

Zengen’s researchers also conducted a separate study on melanocortin receptors that was published in the February 2004 issue of the Journal of Leukocyte Biology. The study, titled, "Autocrine inhibitory influences of alpha-melanocyte-stimulating hormone in malignant pleural mesothelioma," showed that activation of express melanocortin 1 receptor (MC1R) by selective peptides or peptidomimetics might provide a novel strategy to reduce mesothelioma cell proliferation by taking advantage of an endogenous inhibitory circuit based on alpha-Melanocyte-Stimulating Hormone ((-MSH), and its receptor MC1R.

About Zengen, Inc.

Founded in 1999, Zengen, Inc. is a biopharmaceutical company focused on discovering, developing and commercializing innovative products to treat and prevent infection and inflammation through application of its proprietary peptide technologies. Zengen is currently conducting Phase I/II clinical trials for CZEN 002, one of the Company’s proprietary peptide molecules, for the treatment of vulvovaginal candidiasis, commonly known as vaginal yeast infection. For more information about Zengen, please visit www.zengen.com.

Kumiko Hakushi | Ruder Finn, Inc.

More articles from Health and Medicine:

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Researchers at IST Austria define function of an enigmatic synaptic protein

22.11.2017 | Life Sciences

Fine felted nanotubes: CAU research team develops new composite material made of carbon nanotubes

22.11.2017 | Materials Sciences

Women and lung cancer – the role of sex hormones

22.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>