Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic study helps patients with pancreatic cancer experience significantly less pain

03.03.2004


The intense pain many patients with pancreatic cancer experience may be reduced by more than 50 percent using a nerve block technique along with the standard pain-relieving medications. That is the finding of a Mayo Clinic study that will be published in the March 3 edition of the Journal of the American Medical Association (JAMA).



The study also found that the neurolytic celiac plexus block (NCPB), the type of nerve block used, continued to provide sustained pain relief over several months. This benefit may allow some patients with advanced pancreatic cancer to live more comfortably for the duration of their lives.

The Mayo Clinic study is the largest research study to date on managing pain in patients with pancreatic cancer, using the NCPB technique along with pain-relieving medications compared to pain-relieving medications alone. The study was led by Gilbert Wong, M.D., a Mayo Clinic anesthesiologist specializing in pain medicine, who also heads the Mayo Clinic Cancer Center’s Psychosocial Oncology Group.


"The pain caused by pancreatic cancer ranks among the most horrible pains anyone can experience or imagine," says Dr. Wong. "Previous research studies have suggested that 85 percent of patients with advanced disease can experience significant pain."

Pancreatic cancer is an aggressive tumor associated with a high mortality. This year an estimated 31,000 people in the United States will be diagnosed with pancreatic cancer and the majority of them will die within a year.

The Mayo Clinic study involved 100 patients who had advanced pancreatic cancer that could not be surgically removed, and were experiencing significant pain. The patients were randomly assigned to receive either the NCPB or potent pain-relieving medications alone, such as morphine, which is typical treatment for cancer pain. Subsequently, all patients could receive additional pain-relieving medications as needed. All of the patients were followed until death or for at least one year after enrolling in the study.

"Pain-relieving medications alone provided the patients with a 27 percent reduction in pain," Dr. Wong says. "Our goal was to find a better way to further reduce the pain and thereby help them live their remaining time more comfortably.

"We found that patients who also received the NCPB reported a greater than 50 percent reduction in their pain, almost twice the relief that patients who received only the pain-relieving medications got," says Dr. Wong. "Equally as important, we found that the pain relief from the combination of nerve block and pain-relieving medications lasted longer, helping some patients for the duration of their illness."

Pancreatic cancer often shows no warning signs until the tumor has grown to the point that it cannot be surgically removed. Then, approximately 80 percent of patients begin to have significant pain in the upper abdomen and mid-back. By that time, however, the cancer is often advanced and the average survival time is about six months.

"The findings of our study suggest the nerve block technique works for a substantial number of patients with advanced pancreatic cancer and should be considered as a treatment option," says Dr. Wong. "It’s an important benefit to patients with pancreatic cancer and important information for physicians who take care of them."

Study Details

One hundred patients with nonresectable pancreatic cancer and experiencing significant pain were enrolled between October 1997 and January 2001 and followed until demise or at least one year. Baseline pain was similar among patients assigned to receive the NCPB and those receiving systemic analgesic therapy (SAT) alone.

In the first week of treatment, patients in both groups reported less intense pain and improved quality of life, but patients receiving the NCPB had a larger decrease in pain than patients receiving SAT. At six weeks, fewer patients receiving the NCPB reported moderate or severe pain compared to SAT patients. Repeated analysis through the first six months after enrolling in the study showed NCPB patients had significantly lower pain over time than SAT patients. However, consumption of opioids and frequency of opioid side effects, such as sleepiness, nausea and constipation, were not significantly different between the two groups.

One year after enrolling in the study, 16 percent of patients receiving the NCPB and six percent of SAT patients were still alive.


The Mayo Clinic study, titled "Effects of Neurolytic Celiac Plexus Block on Pain Relief, Quality of Life and Survival in Patients with Unresectable Pancreatic Cancer," was funded with grants from FAER -- Foundation for Anesthesia, Education and Research, Cancer Treatment Research Foundation, and the Ehlers Family for Psychosocial Oncology and Spiritual Care Research at the Mayo Clinic Cancer Center.

To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories

Mary Lawson | EurekAlert!
Further information:
http://www.mayoclinic.org/news
http://www.mayoclinic.com

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>