Data from unique gene function studies show Rb is required for proliferation of retinal cells and development of the light-sensitive rods and gives hints for improving treatment of retinoblastoma
The finding that a tumor-suppressor protein called Rb is required for proper development of the mouse retina is a major step toward understanding why some children develop the devastating eye cancer called retinoblastoma. This discovery should eventually help scientists design a better treatment for this disease, according to investigators at St. Jude Childrens Research Hospital. An article about this research is published in the Feb. 29 issue of Nature Genetics.
The St. Jude team showed that Rb limits the proliferation of immature retinal cells so the retina develops to a normal size. The Rb protein also prompts specific cells to develop into light-sensitive cells called rods.
Bonnie Cameron | EurekAlert!
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