Disulfiram (a drug used to help selected patients with alcohol disorders remain sober) and cognitive behavioral therapy appear effective in reducing cocaine use, especially among cocaine users who are not dependent on alcohol, according to an article in the March issue of The Archives of General Psychiatry, one of the JAMA/Archives journals.
Patients taking disulfiram who ingest even small amounts of alcohol develop a reaction that produces nausea, flushing, vomiting, and throbbing headache. At times, this reaction can be severe and can lead to critical illness, such as severe respiratory problems, circulatory problems, or even death. According to the article, alcohol is a powerful "cue" for using cocaine, and can impair judgment and lower resistance to cravings for cocaine. Researchers hypothesize that by reducing alcohol use with disulfiram, users might be less likely to abuse cocaine. However, use of disulfiram has not been evaluated in general populations of cocaine users.
Kathleen M. Carroll, Ph.D., from Yale University School of Medicine, New Haven, Conn., and colleagues randomly assigned 121 cocaine-dependent adults (average age, 34.6 years) to receive either disulfiram or placebo over a 12-week period. Participants were also randomized to participate in either cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT, a less structured form of behavioral therapy).
Jacqueline Weaver | EurekAlert!
GLUT5 fluorescent probe fingerprints cancer cells
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At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
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Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
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University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
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Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
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