Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Finnish families guide to gene behind abnormal lipid levels and atherosclerosis

01.03.2004


Coronary heart disease is the leading cause of death in Western societies. Unfavorable serum lipid levels, high cholesterol, high triglycerides and low high-density lipoprotein (HDL) cholesterol, are well-known risk factors for atherosclerosis and coronary heart disease. Familial combined hyperlipidemia (FCHL), characterized by these changes in patients serum is the most common familial lipid disorder predisposing to coronary heart disease. FCHL is observed in about 20% of coronary heart disease patients under 60 years and the prevalence being 1% to 2% of Western populations. FCHL is a multifactorial lipid disorder caused by several genes and environmental factors. However, its etiology has remained largely unknown, leaving a significant number of affected individuals without proper prevention and care exposed to coronary heart disease.



The Finnish U.S. research team earlier reported the location of the FCHL gene on chromosome 1q (Pajukanta et al. Nature Genetics 1998) and has now identified the first major gene for FCHL, the most common hyperlipidemia predisposing to coronary heart disease (Pajukanta, Nature Genetics 2004).

The hyperlipidemia gene encodes the upstream transcription factor 1 (USF1) that regulates several genes participating in glucose and lipid metabolism. Since the same chromosome 1q21 region has also been linked to type 2 diabetes mellitus (T2DM) in numerous studies, it raises the possibility that the USF1 gene may explain the molecular background of not only hyperlipidemias but also the metabolic syndrome and type 2 diabetes. The study was performed by research groups lead by Professors Leena Peltonen, Paivi Pajukanta, Christian Ehnholm, Marja-Riitta Taskinen and Markku Laakso in the National Public Health Institute of Finland, in the University of California, Los Angeles (UCLA), USA, and in the Universities of Helsinki and Kuopio, Finland.


The discovery of the genetic basis for FCHL and its component traits (high serum total cholesterol, triglycerides and low HDL), will help develop more accurate diagnostic and preventive tools as well as biology-based therapeutic strategies for this common lipid disorder predisposing to coronary heart disease and perhaps also to metabolic syndrome, a growing health problem in Western countries.

Reference: Pajukanta et al. Nature Genetics, April 2004

More information: Leena Peltonen. Tel: 358-9-4744-83939, email: leena.peltonen@ktl.fi

Minna Meriläinen | alfa
Further information:
http://www.helsinki.fi/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>