Coronary heart disease is the leading cause of death in Western societies. Unfavorable serum lipid levels, high cholesterol, high triglycerides and low high-density lipoprotein (HDL) cholesterol, are well-known risk factors for atherosclerosis and coronary heart disease. Familial combined hyperlipidemia (FCHL), characterized by these changes in patients serum is the most common familial lipid disorder predisposing to coronary heart disease. FCHL is observed in about 20% of coronary heart disease patients under 60 years and the prevalence being 1% to 2% of Western populations. FCHL is a multifactorial lipid disorder caused by several genes and environmental factors. However, its etiology has remained largely unknown, leaving a significant number of affected individuals without proper prevention and care exposed to coronary heart disease.
The Finnish U.S. research team earlier reported the location of the FCHL gene on chromosome 1q (Pajukanta et al. Nature Genetics 1998) and has now identified the first major gene for FCHL, the most common hyperlipidemia predisposing to coronary heart disease (Pajukanta, Nature Genetics 2004).
The hyperlipidemia gene encodes the upstream transcription factor 1 (USF1) that regulates several genes participating in glucose and lipid metabolism. Since the same chromosome 1q21 region has also been linked to type 2 diabetes mellitus (T2DM) in numerous studies, it raises the possibility that the USF1 gene may explain the molecular background of not only hyperlipidemias but also the metabolic syndrome and type 2 diabetes. The study was performed by research groups lead by Professors Leena Peltonen, Paivi Pajukanta, Christian Ehnholm, Marja-Riitta Taskinen and Markku Laakso in the National Public Health Institute of Finland, in the University of California, Los Angeles (UCLA), USA, and in the Universities of Helsinki and Kuopio, Finland.
Minna Meriläinen | alfa
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences