Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Finnish families guide to gene behind abnormal lipid levels and atherosclerosis

01.03.2004


Coronary heart disease is the leading cause of death in Western societies. Unfavorable serum lipid levels, high cholesterol, high triglycerides and low high-density lipoprotein (HDL) cholesterol, are well-known risk factors for atherosclerosis and coronary heart disease. Familial combined hyperlipidemia (FCHL), characterized by these changes in patients serum is the most common familial lipid disorder predisposing to coronary heart disease. FCHL is observed in about 20% of coronary heart disease patients under 60 years and the prevalence being 1% to 2% of Western populations. FCHL is a multifactorial lipid disorder caused by several genes and environmental factors. However, its etiology has remained largely unknown, leaving a significant number of affected individuals without proper prevention and care exposed to coronary heart disease.



The Finnish U.S. research team earlier reported the location of the FCHL gene on chromosome 1q (Pajukanta et al. Nature Genetics 1998) and has now identified the first major gene for FCHL, the most common hyperlipidemia predisposing to coronary heart disease (Pajukanta, Nature Genetics 2004).

The hyperlipidemia gene encodes the upstream transcription factor 1 (USF1) that regulates several genes participating in glucose and lipid metabolism. Since the same chromosome 1q21 region has also been linked to type 2 diabetes mellitus (T2DM) in numerous studies, it raises the possibility that the USF1 gene may explain the molecular background of not only hyperlipidemias but also the metabolic syndrome and type 2 diabetes. The study was performed by research groups lead by Professors Leena Peltonen, Paivi Pajukanta, Christian Ehnholm, Marja-Riitta Taskinen and Markku Laakso in the National Public Health Institute of Finland, in the University of California, Los Angeles (UCLA), USA, and in the Universities of Helsinki and Kuopio, Finland.


The discovery of the genetic basis for FCHL and its component traits (high serum total cholesterol, triglycerides and low HDL), will help develop more accurate diagnostic and preventive tools as well as biology-based therapeutic strategies for this common lipid disorder predisposing to coronary heart disease and perhaps also to metabolic syndrome, a growing health problem in Western countries.

Reference: Pajukanta et al. Nature Genetics, April 2004

More information: Leena Peltonen. Tel: 358-9-4744-83939, email: leena.peltonen@ktl.fi

Minna Meriläinen | alfa
Further information:
http://www.helsinki.fi/

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>