Coronary heart disease is the leading cause of death in Western societies. Unfavorable serum lipid levels, high cholesterol, high triglycerides and low high-density lipoprotein (HDL) cholesterol, are well-known risk factors for atherosclerosis and coronary heart disease. Familial combined hyperlipidemia (FCHL), characterized by these changes in patients serum is the most common familial lipid disorder predisposing to coronary heart disease. FCHL is observed in about 20% of coronary heart disease patients under 60 years and the prevalence being 1% to 2% of Western populations. FCHL is a multifactorial lipid disorder caused by several genes and environmental factors. However, its etiology has remained largely unknown, leaving a significant number of affected individuals without proper prevention and care exposed to coronary heart disease.
The Finnish U.S. research team earlier reported the location of the FCHL gene on chromosome 1q (Pajukanta et al. Nature Genetics 1998) and has now identified the first major gene for FCHL, the most common hyperlipidemia predisposing to coronary heart disease (Pajukanta, Nature Genetics 2004).
The hyperlipidemia gene encodes the upstream transcription factor 1 (USF1) that regulates several genes participating in glucose and lipid metabolism. Since the same chromosome 1q21 region has also been linked to type 2 diabetes mellitus (T2DM) in numerous studies, it raises the possibility that the USF1 gene may explain the molecular background of not only hyperlipidemias but also the metabolic syndrome and type 2 diabetes. The study was performed by research groups lead by Professors Leena Peltonen, Paivi Pajukanta, Christian Ehnholm, Marja-Riitta Taskinen and Markku Laakso in the National Public Health Institute of Finland, in the University of California, Los Angeles (UCLA), USA, and in the Universities of Helsinki and Kuopio, Finland.
Minna Meriläinen | alfa
Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin
One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
27.06.2017 | Power and Electrical Engineering
27.06.2017 | Information Technology
27.06.2017 | Physics and Astronomy