Short-Term Hormone Replacement Therapy Safe Following Removal of Ovaries
Two studies from the Abramson Cancer Center at the University of Pennsylvania appearing online in the Journal of Clinical Oncology (JCO) have important implications for women with BRCA1 and BRCA2 mutations. The first study shows that bilateral prophylactic mastectomy can reduce breast cancer risk by more than 90% in women with BRCA1 and BRCA2 mutations, and may be even more effective when performed concurrently with or following oophorectomy. The second study shows that women undergoing prophylactic oophorectomy (removal of ovaries) can take short-term hormone replacement therapy (HRT) to combat the associated symptoms of menopause without fear of significantly increasing breast cancer risk.
Although the removal of the breasts and the ovaries does not completely prevent breast and ovarian cancer, researchers strongly recommend that all women with the mutations undergo oophorectomy at the completion of child bearing, based on previous studies showing that this procedure reduces ovarian cancer risk by at least 90%. Results of these studies will be published online at www.jco.org on February 23, 2004 at 6:00 p.m. (ET).
Carrie Housman | EurekAlert!
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