Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Kidney transplant patients who develop diabetes show poor short-term outcomes


Patients who develop diabetes shortly after kidney transplantation have poorer short-term outcomes than those who had the disease before transplant, according to a Penn State Milton S. Hershey Medical Center study.

"Because patients with diabetes often pose many medical challenges due to the complications of the disease, it was surprising to see that these patients who’d been dealing with diabetes for years, ended up better off than the patients who only developed diabetes after their transplants," said Robert Gabbay, M.D., Ph.D., associate professor of medicine, co-director, Penn State Diabetes Center, and principal investigator of the study, which appeared in the December 2003 issue of Transplantation Proceedings. "Overall, patients who developed post-transplant diabetes were most vulnerable to kidney rejection, infection and additional hospitalization."

The study included 181 kidney transplant patients at Penn State Milton S. Hershey Medical Center from January 1999 to December 2000. The patients were divided into three groups: those who had diabetes prior to kidney transplant, those who developed diabetes mellitus within 24 weeks after transplant; and those who did not have diabetes mellitus before or after transplant. Data was collected before and after the patients’ transplants.

Results showed that about 22 percent of previously non-diabetic patients developed post-transplant diabetes within six months of kidney transplant. About 57 percent of those patients developed an infection compared to 35 percent of patients who had diabetes prior to transplant and 21 percent of patients who did not have or develop diabetes. Patients who developed post-transplant diabetes also were more likely to have recurrent infections than the other two patient groups.

"We would expect that patients who were recently diagnosed with diabetes wouldn’t yet be suffering from complications, yet our study showed that they do have poorer kidney transplant outcomes," Gabbay said.

Although few in number, previous long-term studies showed that the standard post-transplant drug therapies taken to help patients avoid organ rejection can actually cause patients to develop diabetes. Limited data form other studies also has suggested that post-transplant diabetes is associated with higher rates of long-term sickness and death primarily due to an increase in infections or heart and vascular problems.

"This study focused on the first six months after transplant because short term rehospitalization is a great concern for transplant patients," Gabbay said. "If bad outcomes start early, then earlier interventions may be helpful for the long-term health of the patients." Gabbay said the health information presented in the long-term outcomes studies may include influences from other medical complications of diabetes. Focusing on the short term may remove any influences from the long-term complications of diabetes and allow the researchers to focus on the glucose values. Tight control of glucose, or blood sugar, with the use of insulin is important for all patients with diabetes to remain healthy.

"We believe that the poor outcomes in those who develop diabetes after kidney transplant may have something to do with glucose levels and we plan to study that next," Gabbay said. "We hope that medical interventions early could lead to better outcomes for these patients in the long run."

Co-authors on the study were: T.F.M. Saleem, M.D., fellow; K.E. Cunningham, medical student, Penn State College of Medicine, C.S. Hollenbeak, Ph.D., assistant professor of surgery and health evaluation sciences; and E. J. Alfrey, M.D., professor of surgery, Penn State College of Medicine, Penn State Hershey Medical Center.

Penn State Diabetes Center is a partnership of scientists and medical specialists whose continued goal is to increase the scientific and medical knowledge needed to eradicate diabetes, and help those with diabetes to live better, healthier lives. Penn State Diabetes Center is piloting a new integrated system – the first of its kind in Pennsylvania and only the second in the nation – to help primary care physicians to make sure that patients with diabetes are getting all of the recommended screenings and tests.

Valerie Gliem | EurekAlert!
Further information:

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>