Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What are your odds of surviving into your hundreds?

18.02.2004


A genetic factor that protects you against heart disease during middle age could reduce the odds that you’ll celebrate your hundredth birthday. Research published in BMC Medical Genetics shows that a genetic trait, which is rarely found in centenarians, is associated with lower cholesterol levels.

The risk of suffering from heart disease is increased by a number of factors, including having high levels of low-density lipoprotein cholesterol in your blood. The main component of low-density lipoprotein is apoliprotein(b) whose quality and quantity are related to the quality and expression of the APOB genes you have.

In a previous study, Professor Giovanna De Benedictis found that older, healthy people were most unlikely to carry short versions of a DNA region that neighbours the APOB gene. "This indicates that the short alleles are unfavourable to longevity," she says. In contrast, these short versions are over-represented in healthy, middle-aged adults, indicating that these variants of the APOB gene region play a protective role at this point in your life.

Her group have now analysed both the variability in the DNA surrounding the APOB gene and the low-density lipoprotein cholesterol levels in over 400 healthy volunteers, between the ages of 20 and 102. The aim was to see if there was any link between the two factors.

Their results show that people with short variants of the APOB gene region have significantly lower levels of total cholesterol and low-density lipoprotein cholesterol in their blood.

The authors of the study write: "On the whole, the short alleles would be advantageous in adults, by protecting them from high levels of LDL-Cholesterol, while dangerous in the elderly, probably by lowering serum cholesterol below a critical threshold."

In line with these findings, the researchers showed that patients suffering from heart disease as a consequence of having high low-density lipoprotein cholesterol levels were less likely to have one or more short variants of the APOB gene region, compared to healthy volunteers.

"On the whole, the study confirms that genetic risk factors are age-specific and gives possible insights into another ’paradox of centenarians’," write the authors.



This press release is based on the following article:

A study of the average effect of the 3’APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians.
S Garasto, M Berardelli, F De Rango, V Mari, E Geraco and G De Benedictis


BMC Medical Genetics, 2004 5:3
Published 9 February, 2004

Gemma Bradley | BioMed Central
Further information:
http://www.biomedcentral.com/1471-2350/5/3/
http://www.biomedcentral.com/bmcmedgenet

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>