Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hormone released by bone marrow cells may hasten recovery from brain injury

13.02.2004


Bone marrow stromal cells release a blood vessel-dilating hormone found in the brain -- a finding that suggests the hormone may be tapped to help with recovery from stroke or other neurological injuries disrupting blood flow to the central nervous system, researchers at the University of South Florida and James A. Haley Veterans’ Hospital report for the first time. The hormone is known as brain natriuretic peptide.



The laboratory study was published in the January 2004 issue of the journal Experimental Neurology.

"We’re suggesting that transplanted bone marrow stromal cells may hasten recovery by releasing brain natriuretic peptide and other factors that improve blood flow to the brain and decrease swelling and pressure around the site of injury," said lead investigator Juan Sanchez-Ramos, MD, PhD, professor of neurology and research director at the USF Center for Aging and Brain Repair. "By helping irrigate, or restore the blood circulation to the brain, brain natriuretic factor may reduce the extent of damage from stroke or spinal cord injuries."


Researchers at USF and other institutions have demonstrated that some cells from adult bone marrow can be converted with growth factors and other agents into immature nerve cells -- both in the laboratory and following transplant into animals. Furthermore, rats suffering from stroke or other traumatic brain injury recover neurological function quicker following intravenous infusions of bone marrow stromal cells.

However, no one has proven that this recovery results from converted bone marrow cells directly replacing or repairing damaged neurons. A growing number of scientists, including Dr. Sanchez-Ramos, hypothesize that growth factors, cytokines and other substances secreted by bone marrow cells may play a more important role than first realized in recovery from neurological injuries.

The USF researchers identify bone marrow-derived brain natriuretic factor (BNP) as a potential candidate for treating stroke, spinal cord injury and other neurological damage. Although found in the brain, BNP belongs to a family of atrial natriuretic peptides, hormones made by the heart that exhibit powerful diuretic and blood pressure-lowering characteristics. In rat models of stroke, these atrial natriuretic peptides have been reported to decrease brain swelling or edema.

Human bone marrow is capable of producing significant amounts of BNP, the USF researchers demonstrated. Bone marrow stromal cells grown in the laboratory secreted levels of BNP far exceeding the amounts normally found in circulating blood and spinal fluid.

The researchers next plan to measure the effects of BNP from bone marrow cells transplanted into rats with strokes and spinal cord injuries.

Anne DeLotto Baier | EurekAlert!
Further information:
http://hsc.usf.edu/

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>