Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hormone released by bone marrow cells may hasten recovery from brain injury

13.02.2004


Bone marrow stromal cells release a blood vessel-dilating hormone found in the brain -- a finding that suggests the hormone may be tapped to help with recovery from stroke or other neurological injuries disrupting blood flow to the central nervous system, researchers at the University of South Florida and James A. Haley Veterans’ Hospital report for the first time. The hormone is known as brain natriuretic peptide.



The laboratory study was published in the January 2004 issue of the journal Experimental Neurology.

"We’re suggesting that transplanted bone marrow stromal cells may hasten recovery by releasing brain natriuretic peptide and other factors that improve blood flow to the brain and decrease swelling and pressure around the site of injury," said lead investigator Juan Sanchez-Ramos, MD, PhD, professor of neurology and research director at the USF Center for Aging and Brain Repair. "By helping irrigate, or restore the blood circulation to the brain, brain natriuretic factor may reduce the extent of damage from stroke or spinal cord injuries."


Researchers at USF and other institutions have demonstrated that some cells from adult bone marrow can be converted with growth factors and other agents into immature nerve cells -- both in the laboratory and following transplant into animals. Furthermore, rats suffering from stroke or other traumatic brain injury recover neurological function quicker following intravenous infusions of bone marrow stromal cells.

However, no one has proven that this recovery results from converted bone marrow cells directly replacing or repairing damaged neurons. A growing number of scientists, including Dr. Sanchez-Ramos, hypothesize that growth factors, cytokines and other substances secreted by bone marrow cells may play a more important role than first realized in recovery from neurological injuries.

The USF researchers identify bone marrow-derived brain natriuretic factor (BNP) as a potential candidate for treating stroke, spinal cord injury and other neurological damage. Although found in the brain, BNP belongs to a family of atrial natriuretic peptides, hormones made by the heart that exhibit powerful diuretic and blood pressure-lowering characteristics. In rat models of stroke, these atrial natriuretic peptides have been reported to decrease brain swelling or edema.

Human bone marrow is capable of producing significant amounts of BNP, the USF researchers demonstrated. Bone marrow stromal cells grown in the laboratory secreted levels of BNP far exceeding the amounts normally found in circulating blood and spinal fluid.

The researchers next plan to measure the effects of BNP from bone marrow cells transplanted into rats with strokes and spinal cord injuries.

Anne DeLotto Baier | EurekAlert!
Further information:
http://hsc.usf.edu/

More articles from Health and Medicine:

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

nachricht Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>