A team of cell biologists at the Stanford University School of Medicine has developed a new imaging technique using biosensors that precisely monitor the timing of cell division. Researchers tested the technique by observing and measuring the slowdown of cell division associated with an anti-cancer drug. They believe the discovery may allow them to screen for many more anti-cancer compounds in the future.
Tissues and organs form and grow through a highly regulated process of cell division known as mitosis. Normally, cells stop dividing once they start performing specialized functions. If the process is incorrectly regulated, however, cells divide too fast or too slowly. Accelerated cell division can result in cancers that proliferate rapidly unless anti-cancer agents intervene.
To measure cell division timing, the researchers incorporated fluorescent proteins, called biosensors, into the cell nuclei. When used with a specialized microscopy technique called total internal reflection fluorescence, the biosensor glows when the nuclear membrane breaks down, passes through the surrounding cellular material and is released into the cell membrane. When genetic material is re-enclosed in the nuclear envelope of newly formed cells, the biosensor moves back into the reformed nucleus and there is no fluorescence. The effect is like a light switch being turned on and off, signaling the start and end of the cell division process, respectively.
Rosanne Spector | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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