A team of cell biologists at the Stanford University School of Medicine has developed a new imaging technique using biosensors that precisely monitor the timing of cell division. Researchers tested the technique by observing and measuring the slowdown of cell division associated with an anti-cancer drug. They believe the discovery may allow them to screen for many more anti-cancer compounds in the future.
Tissues and organs form and grow through a highly regulated process of cell division known as mitosis. Normally, cells stop dividing once they start performing specialized functions. If the process is incorrectly regulated, however, cells divide too fast or too slowly. Accelerated cell division can result in cancers that proliferate rapidly unless anti-cancer agents intervene.
To measure cell division timing, the researchers incorporated fluorescent proteins, called biosensors, into the cell nuclei. When used with a specialized microscopy technique called total internal reflection fluorescence, the biosensor glows when the nuclear membrane breaks down, passes through the surrounding cellular material and is released into the cell membrane. When genetic material is re-enclosed in the nuclear envelope of newly formed cells, the biosensor moves back into the reformed nucleus and there is no fluorescence. The effect is like a light switch being turned on and off, signaling the start and end of the cell division process, respectively.
Rosanne Spector | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy