Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early fevers associated with lower allergy risk later in childhood

10.02.2004


Infants who experience fevers before their first birthday are less likely to develop allergies by ages six or seven, according to a new study funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The study, published today in the Journal of Allergy and Clinical Immunology, lends support to the well-known "hygiene hypothesis," which contends that early exposure to infections might protect children against allergic diseases in later years.



The prevalence of asthma and allergies has increased dramatically worldwide in recent years," says Anthony S. Fauci, M.D., director of NIAID. "This study provides evidence that diminished exposure to early immunological challenges could be one of the reasons for this trend."

"The hygiene hypothesis is widely recognized but largely unproven," says Kenneth Adams, Ph.D., who oversees asthma research funded by NIAID. "The findings of this study strengthen the hypothesis and, after more research, could lead to preventative therapies for asthma and allergies."


The authors of the study followed the medical records of 835 children from birth to age 1, documenting any fever-related episodes. Fever was defined as a rectal temperature of 101 degrees Fahrenheit or above. At age 6 to 7 years, more than half of the children were evaluated for their sensitivity to common allergens, such as dust mites, ragweed and cats.

Researchers found that, of the children who did not experience a fever during their first year, 50.0 percent showed allergic sensitivity. Of those who had one fever, 46.7 percent became allergy-prone. The children who suffered two or more fevers in their infancy had greater protection, with only 31.3 percent showing allergic sensitivity by ages 6 to 7.

In particular, fever-inducing infections involving the eyes, ears, nose or throat appeared to be associated with a lower risk of developing allergies, compared with similar infections that did not result in fevers.

"We didn’t expect fever to relate with such a consistent effect," says Christine C. Johnson, Ph.D, M.P.H., senior research epidemiologist of the Henry Ford Health System in Detroit, MI, and one of the co-authors of the study. "It also was interesting that the more fevers an infant had, the less likely it was that he or she would be sensitive to allergies."

Dr. Johnson says that more research is needed to establish if early fevers have a direct effect on allergic development in children. Additionally, she and the other authors are working to determine if early exposure to pets as well as high levels of bacteria could also lower allergy risk. "If we can uncover which environmental factors affect allergic development and why, it may be possible to immunize children against these conditions," she says.


###
This study also received support from the National Institute of Environmental Health Sciences, another NIH component.

NIAID is a component of the National Institutes of Health (NIH), an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies.

Reference:

L Keoki Williams et al. The relationship between early fever and allergic sensitization at age 6 to 7 years. Journal of Allergy and Clinical Immunology 113(2): 291-296 (2004).

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

Paul Williams | NIAID News
Further information:
http://www.niaid.nih.gov/newsroom/releases/earlyfevers.htm
http://www.niaid.nih.gov

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>