Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New data show botulinum toxin type A to be highly effective treatment for excessive sweating

09.02.2004


Results of a Phase III clinical study using botulinum toxin type A to treat primary axillary hyperhidrosis, or excessive underarm sweating, show that botulinum toxin type A is safe and effective for treatment of hyperhidrosis and that it markedly improves quality of life in patients who suffer from this medical condition. The data were announced today at the 2004 American Academy of Dermatology (AAD) annual meeting in Washington, D.C. by Dr. Dee Anna Glaser, Associate Professor of Dermatology and Vice Chairman, Department of Dermatology, at Saint Louis University School of Medicine, a lead investigator for the trials.



"Most people don’t realize that hyperhidrosis is an extremely debilitating chronic condition that affects as many as eight million people in the U.S.," said Dr. Glaser. "As such, the results of this 52-week study using botulinum toxin type A treatment are very exciting because they mean that we are that much closer to having the first truly effective, non-surgical treatment available to meet the needs of patients who suffer from primary axillary hyperhidrosis."

The study found that four weeks after treatment with botulinum toxin type A (administered intradermally), 75 percent of patients receiving botulinum toxin type A vs. 25 percent on placebo achieved at least a 2-point improvement from baseline on the Hyperhidrosis Severity Scale (HDSS), a 4-point scale. Quantity of sweat production in the axillae was also significantly decreased.


"The Hyperhidrosis Severity Scale is an important new tool that physicians can use to identify hyperhidrosis patients who are in need of medical treatment, as well as to assess treatment results over time," explains Dr. Glaser. "It is our hope that physicians will begin to use this valid and reliable scale to quickly and accurately diagnose patients with hyperhidrosis who otherwise might not seek treatment."

The study also assessed the specific effects of primary axillary hyperhidrosis on patients’ daily lives at study entry (prior to receiving treatment) and again four weeks after receiving his/her study treatment. It found that hyperhidrosis results in substantial occupational, psychological and physical impairment for the patient, and that botulinum toxin type A treatment markedly improved patients’ quality of life as soon as four weeks after initial treatment.

"People who suffer from hyperhidrosis have a very hard time leading a normal life," said Dr. Glaser. "While there is a general misperception that hyperhidrosis is merely a disturbing hygienic issue, the condition should be taken seriously as it could lead to isolation and depression. It is important that physicians are made aware of hyperhidrosis and available treatment options to ensure patients receive proper diagnosis and are not just sent away with instructions to buy a stronger anti-perspirant."

Safety and Efficacy - Methodology and Results

Following screening, 322 patients were randomized to one of three treatment groups (50 units of botulinum toxin type A per underarm, 75 units of botulinum toxin type A per underam or placebo) and were evaluated at one week after treatment and every four weeks thereafter. The primary efficacy evaluation was patient assessment of hyperhidrosis severity using the Hyperhidrosis Disease Severity Scale (HDSS).

Four weeks after treatment session one, the following results were observed:
  • 75 percent of patients in each botulinum toxin type A group and 25 percent of placebo patients achieved at least a two-grade improvement from baseline on the HDSS;

  • 43 percent of patients treated with botulinum toxin type A required only one treatment for the entire one-year study period, versus 12 percent on placebo;

  • Mean sweat production was significantly decreased in both botulinum toxin type A groups four weeks after their initial treatment (82 percent, 87 percent and 22 percent decreases in the 50U, 75U and placebo groups respectively);

  • Upon completion of the study, 85 percent and 84 percent of patients treated with 50U and 75U of botulinum toxin type A respectively reported that they were much more satisfied with the current study treatment than with previous treatments, versus 20 percent of patients on placebo;

  • There was no difference between the 50U and 75U groups in terms of measured efficacy endpoints.

No serious treatment-related adverse events were reported. The most frequently reported treatment-related adverse events (>5 percent in any treatment group) were injection site pain, injection site hemorrhage and non-axillary sweating. The incidence of these events was not significantly different between groups.

In related research presented by Dr. Glaser at the meeting, data from the 322 patient study were used to assess the validity of the HDSS by correlating HDSS scores with items from the Dermatology Quality of Life Index and the HHIQ four weeks post-treatment. Construct validity and responsiveness were assessed by comparing post-treatment changes in HDSS score with changes in gravimetric sweat measurement and by comparing HDSS scores with various daily activity limitations due to excessive sweating as collected in a national survey mailed to 150,000 U.S. households.

Based on resulting data from these analyses, the HDSS was observed to have acceptable validity, reliability and responsiveness.


This study was funded by Allergan, Inc.

Joe Muehlenkamp | EurekAlert!
Further information:
http://www.slu.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>