Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood-diverting catheter holds promise for stroke treatment

06.02.2004


American Stroke Association meeting report



A new catheter device that diverts some blood from the lower body to the brain appears safe for treating acute stroke and may significantly reduce stroke complications – even after a critical treatment window has lapsed.

The results of this experimental study were reported today at the American Stroke Association’s 29th International Stroke Conference.


"The device treats stroke by a unique approach that increases blood flow to the brain," said lead author Morgan S. Campbell III, M.D., director of interventional neurology at the Alabama Neurological Institute, in Birmingham. "Ten of the 15 patients who were conscious when they arrived at the hospital improved during the procedure, which is very impressive."

Campbell and his colleagues tested the safety and effectiveness of the device, called NeuroFlo, on patients who suffered ischemic strokes. Ischemic strokes occur when a blood clot blocks an artery, reducing blood flow and oxygen to part of the brain. Using two balloons attached to a catheter, NeuroFlo diverts some blood from the lower extremities and sends it to the upper body.

Not all the brain cells affected by an ischemic stroke die immediately, Campbell said. A large number of cells in the stroke area initially have the potential to recover if their blood supply is restored. In theory, increasing the volume of blood to these damaged brain cells should preserve some of them even more than three hours after a stroke onset.

Ischemic stroke patients who arrive within three hours of symptom onset can often be treated with clot-busting drugs. However, these clot busters are not recommended for use more than three hours after stroke onset.

"The blood volume theory has been studied before but no one had really shown that it actually works and makes a difference," Campbell said. "So it is very encouraging that the device can divert more oxygenated blood to the brain and that patients get better."

Campbell conducted the study while he was an assistant professor of neurology and radiology at The University of Texas Health Science Center at Houston. He and colleagues at eight medical centers in the United States, Turkey, Germany and Argentina studied 17 patients whose strokes had been in progress for three to 12 hours. The average time between stroke onset and the beginning of treatment was 7.5 hours.

Each patient had a NeuroFlo device inserted into an artery in the groin. The device was then threaded up to the abdominal aorta and positioned with collapsed balloons above and below the renal arteries. The balloons were then inflated to partially obstruct the aorta. The device was left in place for one hour.

"By blowing up these balloons and limiting the blood flow to the lower extremities, we shifted more of the blood flow up to the head," Campbell explained.

This greater volume of blood increased collateral flow, the flow of blood through smaller vessels in the brain. The collateral flow by-passed the blocked section of the artery that was causing the patient’s stroke, and brought needed oxygen to the cells downstream from the blockage.

The study’s primary intent was to test the device’s safety. Although two study participants died, their deaths were attributed to their strokes and not adverse effects of the device. Nor did people treated with the device suffer damage to their kidneys, heart or blood vessels.

The research team also evaluated the patients’ treatment response.

Twelve of 16 patients monitored with ultrasound had a 15 percent increase or more of their cerebral blood flow velocity, with an average boost of 25 percent. Ultrasound waves passing into the skull can measure blood flow velocity. Velocity is an indirect measure of blood flow volume.

The blood pressure in the arteries increased an average of only 6 percent overall and did not increase in five patients. "This shows the increased blood flow did not simply result from an increase in blood pressure but from an increase in blood volume," Campbell said. "This is the desired effect of the device."

The researchers also assessed the degree of deficit of the stroke patients. While undergoing their hour-long treatment, 10 of the 15 conscious patients (67 percent) showed significantly higher scores on the National Institutes of Health Stroke Scale, the most commonly used assessment tool in acute stroke. Thirty days after treatment, six of the 15 survivors had "good" physical function, on the modified Rankin scale, which rates disability.

The second phase of the study has begun enrollment. CoAxia, Inc., the device’s maker, will seek approval from the U.S. Food and Drug Administration to conduct a larger clinical trial.


Co-authors are James C. Grotta, M.D.; Camilo R. Gomez, M.D.; and Gazi Ozdemir, M.D.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>