Researchers also find current immunosuppression drug therapy may be harmful for transplanted Islets
Treating pancreatic islet cells with a growth factor can dramatically reduce the number of these cells needed for transplants to reverse Type 1 diabetes, according to a study by University of Pittsburgh School of Medicine researchers. In the animal model study, researchers also found that the triple-drug immunosuppression therapy currently used after human islet cell transplants is harmful to transplanted rat pancreatic islets and can actually induce diabetes in rats.
"This study suggests that the current immunosuppression regimen might be further optimized or changed and has potential implications for further improving islet transplant outcomes in humans with Type 1 diabetes," said senior author Andrew Stewart, M.D., chief of the division of endocrinology and metabolism and professor of medicine at the University of Pittsburgh School of Medicine.
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