Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sandia-developed foam likely would stop SARS virus quickly, Sandia / Kansas State team shows

03.02.2004


Cecilia Williams (left) and Jill Bieker, two members of the Sandia/K-State research team, inject Sandia’s decontamination formulation into a flask containing a surrogate of the SARS virus. The team has demonstrated the formulation’s ability to inactivate Bovine coronavirus, the internationally accepted surrogate for the SARS virus, in less than a minute. (Photo by Bill Doty)


Sandia researcher Mark Tucker examines two petri dishes: one with a simulant of anthrax growing in it, the other treated with a decontamination formulation developed at Sandia. An earlier version of the formulation was among products used in late 2001 to decontaminate facilities in New York and Washington, D.C., contaminated with anthrax. (Photo by Randy Montoya)


Project’s results might help officials battle emerging viruses such as bird flu

Researchers at the U.S. National Nuclear Security Administration’s Sandia National Laboratories and Kansas State University have shown that chemical formulations previously developed at Sandia to decontaminate chemical and biological warfare agents are likely effective at killing the virus that causes Severe Acute Respiratory Syndrome (SARS).

In a series of tests conducted at Kansas State on Bovine coronavirus (BCV), the internationally accepted surrogate for the SARS coronavirus, Sandia-modified versions of its DF-200 formulation fully inactivated BCV samples in one minute or less.



The team now is pursuing funding to conduct similar tests on the SARS coronavirus and hopes to test other emerging viruses such as the avian influenza virus (bird flu).

Recent research suggests that the SARS virus can remain active on contaminated surfaces for days, and health officials speculate that places where infected people congregate, such as airports and hospital wards, might have served as "superspreaders" during the SARS outbreak.

The Sandia/K-State researchers believe that cleaning facilities with chemicals proven to inactivate the virus might significantly blunt an outbreak and possibly prevent regional epidemics from becoming worldwide epidemics.

Margin of certainty

The Sandia decontamination formulations are designed to be less harsh and easier to use than other chemicals currently used for decontamination of biological agents. Tailored formulations have been under development at Sandia for military and homeland security uses since 1996.

In 2001 the earliest version of the commercially licensed foam were among products used in cleanup efforts at facilities contaminated with anthrax in New York and Washington, D.C.

To give the researchers enough scientific confidence that the formulation would reliably stamp out SARS regardless of the circumstances, the Sandia/K-State team tested the formulations against BCV using cell culture methods with and without organic material present. Organic materials such as soil and feces may improve the survival rate of coronaviruses and can react directly with the disinfectant to make it less effective.

They also used diluted concentrations of the formulation, down to 10 percent of normal, and altered recipes of the formulation with similar results.

"We didn’t want to test the formulations in the best-case scenario," says Cecelia Williams of Sandia. "We wanted the worst-case scenario to provide a margin of certainty that this would inactivate the SARS-causing virus under real-world conditions."

The lower concentration makes the formulation, already much less corrosive and toxic than other decontamination products such as bleach or ammonia, even more benign, she says.

Currently no disinfectant products are registered with the Environmental Protection Agency (EPA) specifically for killing the SARS virus on surfaces.

Two commercially available versions of the Sandia formulation also were effective in inactivating the virus in the tests, she says.

New protocols for viral inactivation

A second significant outcome of the joint research is a set of protocols and a methodology to verify viral inactivation. A SARS workshop in October 2003 sponsored by the World Health Organization identified the standardization of test protocols as one urgent need in responding to future SARS outbreaks.

Currently very little information is available in the scientific literature regarding chemical inactivation of viruses, says team member Jill Bieker, a Sandia intern currently working on a PhD at K-State. The work at K-State was conducted under the guidance of Dr. Sanjay Kapil, a world-renowned coronavirus expert.

As part of the project, Sandia conducted experiments to develop methods of applying the formulation and to determine how inactivation can be measured and verified. The team also modified common laboratory diagnostic tools and assay techniques to test the foam’s efficacy against BCV. The work built on previous efficacy studies on chem-bio agents Sandia had performed for DOE, the military, and the U.S. Department of Homeland Security.

"The protocols developed for this project could be rapidly modified to help provide health officials and researchers around to world with a method of verifying viral inactivation," says Bieker. "It would allow officials to respond more quickly to future disease outbreaks and to quickly identify the disinfection products that work best against a particular virus."

SARS and other viruses

Last winter, spring, and summer, SARS coronavirus infected nearly 8,900 people in 30 countries and caused 774 deaths. Whether a SARS materializes this year on a broad scale remains to be seen. Only a few cases have been confirmed so far in Asia.

The researchers are optimistic that the Sandia formulations could become an effective means of minimizing the spread of returning viruses such as SARS and the Norwalk (cruise ship) virus, emerging infectious diseases such as avian influenza (bird flu), and more common viruses such as influenza.

"Flu and other viruses have similarities that give us reason to believe our formulations would be useful for general viral disinfection and decontamination if used for regular cleaning of certain facilities," says Bieker.

The Sandia decontamination formulations can be deployed as a foam, fog, mist, or spray, meaning they could be sprayed on walls or dispersed as a fog throughout the air-handling system of a building, says Williams.

The work to inactivate SARS is part of a larger Sandia program to develop a toolkit of technologies useful for responding to future infectious disease outbreaks. The program includes research to model air-flow and predict the transport of airborne chemical and biological agents through buildings or aircraft.

Kansas State University is a comprehensive, research, land-grant institution first serving students and the people of Kansas, and also the nation and the world.


Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin company, for the U.S. Department of Energy’s National Nuclear Security Administration. With main facilities in Albuquerque, N.M., and Livermore, Calif., Sandia has major R&D responsibilities in national security, energy and environmental technologies, and economic competitiveness.

Sandia media contact: John German, jdgerma@sandia.gov, (505) 844-5199

Kansas State media contact: Michelle Hall, mhall@k-state.edu , (785) 532-6415

Sandia National Laboratories’ World Wide Web home page is located at http://www.sandia.gov. Sandia news releases, news tips, science photo gallery, and periodicals can be found at the News Center button.

John German | Sandia
Further information:
http://www.sandia.gov/news-center/news-releases/2004/mat-chem/sarsfoam.html
http://www.sandia.gov

More articles from Health and Medicine:

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

nachricht Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>