Kidney dialysis patients with higher cholesterol levels die at a lower rate than those with lower cholesterol levels, which is opposite of the general public. However, a study by researchers at the John Hopkins Bloomberg School of Public Health determined that the lower mortality rate of those with higher cholesterol is likely due to the cholesterol-lowering effects of inflammation and malnutrition, two serious complications of kidney dialysis, and not a benefit of high cholesterol. The study is published in the January 28, 2004, edition of the Journal of the American Medical Association (JAMA).
"Using multiple blood tests we were able to show that the majority of dialysis patients have inflammation and/or malnutrition and these conditions distort the meaning of serum cholesterol. This explains why patients with lower cholesterol have higher mortality," said Josef Coresh, MD, PhD, the studys senior investigator and an associate professor in the Department of Epidemiology at the School of Public Health. "We were able to show that when dialysis patients dont have inflammation or malnutrition, higher cholesterol predicted a progressively higher risk of total and cardiovascular mortality. This is important since it undermines the idea that high cholesterol can be protective in dialysis patients and emphasizes the importance of cholesterol treatment," explained Dr. Coresh.
The study included 823 dialysis patients from 79 clinics in the United States. Inflammation and/or malnutrition were detected by looking for abnormalities in any one of three laboratory tests (C-reactive protein, interleukin-6 or serum albumin) since any one test can miss patients with abnormalities. Participants with inflammation or malnutrition had lower cholesterol levels than those without either condition. Overall, higher cholesterol was incrementally associated with lower mortality, a finding which confirms other studies in dialysis patients and other sick populations such as smokers and the elderly. This opposite association from the expected higher mortality at higher cholesterol has led some physicians to avoid treating high cholesterol in dialysis patients. However, among patients without inflammation or malnutrition, higher cholesterol was strongly associated with higher mortality.
Kenna Brigham | EurekAlert!
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy